Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Name Email address

Details on Person Patched binds Smoothened

Class:IdReaction:445124
_displayNamePatched binds Smoothened
_doReleaseTRUE
_timestamp2010-12-02 14:35:52
authored[InstanceEdit:444871] Jupe, S, 2009-10-27
compartment[Compartment:876] plasma membrane
created[InstanceEdit:445098] Jupe, S, 2009-10-27
edited[InstanceEdit:532507] Jupe, S, 2010-03-01
inferredFrom
input[CandidateSet:445134] PTCH1,PTCH2 [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:445121] SMO [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:208237] The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
modified[InstanceEdit:445148] Jupe, S, 2009-10-28
[InstanceEdit:507975] Jupe, S, 2010-02-10
[InstanceEdit:517472] Jupe, S, 2010-02-18
[InstanceEdit:517513] Jupe, S, 2010-02-19
[InstanceEdit:532503] Jupe, S, 2010-03-01
[InstanceEdit:532504] Jupe, S, 2010-03-01
[InstanceEdit:532571] Jupe, S, 2010-03-01
[InstanceEdit:532724] Jupe, S, 2010-03-03
[InstanceEdit:532726] Jupe, S, 2010-03-03
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePatched binds Smoothened
output[Complex:445147] PTCH1,PTCH2:SMO [plasma membrane] [Homo sapiens]
regulatedBy[NegativeRegulation:517522] Negative regulation by 'Patched:Hedgehog [plasma membrane]'
releaseDate2010-03-16
reviewed[InstanceEdit:450112] D'Eustachio, P, 2009-12-11
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104788] R-HSA-445124.3
summation[Summation:445099] Smoothened (Smo) is usually classified with family B GPCRs b...
(hasEvent)[Pathway:373080] Class B/2 (Secretin family receptors) [Homo sapiens]
[Pathway:445432] Hedgehog signaling [Homo sapiens]
(updatedInstance)[_UpdateTracker:9782430] Update Tracker - [Reaction:445124] Patched binds Smoothened - v59:[modifyText]
[_UpdateTracker:9789863] Update Tracker - [Reaction:445124] Patched binds Smoothened - v37:[modifyText]
[_UpdateTracker:9790429] Update Tracker - [Reaction:445124] Patched binds Smoothened - v33:[add_removeOutput]
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No pathways have been reviewed or authored by Patched binds Smoothened (445124)