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Details on Person L1 cross linking can activate MAPK cascade components MEK1/2...
| Class:Id | Summation:444937 |
|---|---|
| _displayName | L1 cross linking can activate MAPK cascade components MEK1/2... |
| _timestamp | 2010-03-16 17:38:32 |
| created | [InstanceEdit:444932] Garapati, P V, 2009-10-27 |
| literatureReference | [LiteratureReference:444943] The role of cytoplasmic serine residues of the cell adhesion molecule L1 in neurite outgrowth, endocytosis, and cell migration [LiteratureReference:444908] Activation of the MAPK signal cascade by the neural cell adhesion molecule L1 requires L1 internalization |
| modified | [InstanceEdit:549028] Garapati, P V, 2010-03-16 |
| text | L1 cross linking can activate MAPK cascade components MEK1/2, ERK1/2, as well as Src, Raf-1,and p90rsk. MAP kinase signaling requires endocytosis mediated by Src. ERK2 can phos-phorylate internalized L1 at serine residues 1204 and 1248. This phosphorylation may increase the neurite growth. |
| (summation) | [Reaction:445079] Phosphorylation of L1 by ERK [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by L1 cross linking can activate MAPK cascade components MEK1/2... (444937)
