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Details on Person The tyrosine based sorting motif (YRSLE) in L1CD is required...
| Class:Id | Summation:444928 |
|---|---|
| _displayName | The tyrosine based sorting motif (YRSLE) in L1CD is required... |
| _timestamp | 2009-12-30 21:52:45 |
| created | [InstanceEdit:444932] Garapati, P V, 2009-10-27 |
| literatureReference | [LiteratureReference:444938] L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1 |
| modified | [InstanceEdit:447049] Garapati, P V, 2009-11-19 [InstanceEdit:451256] Garapati, P V, 2009-12-30 |
| text | The tyrosine based sorting motif (YRSLE) in L1CD is required for clathrin mediated endocytosis. Y1176 of the YRSLE motif is phosphorylated by SRC tyrosine kinase associated with lipid rafts in the P-domain of the growth cone. Phosphorylation of Y1176 prevents L1 binding to AP-2, an adaptor required for clathrin mediated internalization of L1. |
| (summation) | [Reaction:445084] Phosphorylation of L1 by SRC [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by The tyrosine based sorting motif (YRSLE) in L1CD is required... (444928)
