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Details on Person CHL1 interacts with alpha1beta1/alpha2beta1 integrins in cis...
| Class:Id | Summation:444914 |
|---|---|
| _displayName | CHL1 interacts with alpha1beta1/alpha2beta1 integrins in cis... |
| _timestamp | 2010-03-16 17:38:27 |
| created | [InstanceEdit:444932] Garapati, P V, 2009-10-27 |
| literatureReference | [LiteratureReference:444951] Close homolog of L1 is an enhancer of integrin-mediated cell migration [LiteratureReference:549034] Close homolog of L1 modulates area-specific neuronal positioning and dendrite orientation in the cerebral cortex |
| modified | [InstanceEdit:451256] Garapati, P V, 2009-12-30 [InstanceEdit:549028] Garapati, P V, 2010-03-16 |
| text | CHL1 interacts with alpha1beta1/alpha2beta1 integrins in cis on the cell surface and promotes intracellular signaling, which stimulates cell migration on extracellular matrix proteins such as collagen-I. The integrin interaction motif, DGEA in the Ig6 domain of CHL1, is necessary to potentiate migration to collagen-I. CHL1 interacts with integrins to mediate radial migration of neural precursors in the development neocortex, and suppresses neuronal branching during migration. |
| (summation) | [Reaction:445068] CHL1 interacts with beta1 integrins [Mus musculus] [Reaction:445088] CHL1 interacts with beta1 integrins [Homo sapiens] |
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No pathways have been reviewed or authored by CHL1 interacts with alpha1beta1/alpha2beta1 integrins in cis... (444914)
