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Details on Person Relaxins are part of a family of peptide hormones that diver...
| Class:Id | Summation:444890 |
|---|---|
| _displayName | Relaxins are part of a family of peptide hormones that diver... |
| _timestamp | 2009-10-27 17:16:55 |
| created | [InstanceEdit:444871] Jupe, S, 2009-10-27 |
| literatureReference | [LiteratureReference:444865] Relaxin: new peptides, receptors and novel actions [LiteratureReference:375241] Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways |
| modified | [InstanceEdit:445098] Jupe, S, 2009-10-27 |
| text | Relaxins are part of a family of peptide hormones that diverged from insulin in early vertebrate evolution to form the insulin-like peptides and relaxins, now often referred to as the relaxin peptide family. All are heterodimers; both chains are cleaved from a common propeptide and cross-linked by 2 disulphide bonds. Humans have 3 true relaxins encoded by 3 related genes, plus several more distantly related insulin-like peptide genes. Non-primates have 2 relaxin genes. The major circulating form of relaxin in humans is relaxin-2, equivalent to relaxin-1 in non-primates. Relaxin-3 is very highly conserved. Little is known about human relaxin-1; several of the insulin-like peptides have no known receptor or function.
There are 4 human G-protein coupled receptors for relaxin family peptides. Relaxin receptor 1 (RXFP1) and relaxin receptor 2 (RXFP2) are also known as LGR7 and LGR8 respectively, members of the LRR-containing G protein-coupled receptors (LGRs). Relaxin-3 receptor 1 (RXFP3) and Relaxin-3 receptor 2 (RXFP4) are unrelated, having more homology with small peptide receptors such as the somatostatin receptors. |
| (summation) | [Pathway:444821] Relaxin receptors [Homo sapiens] |
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