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Details on Person GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors

Class:Id	Reaction:444731
_displayName	GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors
_doRelease	TRUE
_timestamp	2010-12-02 14:41:32
authored	[InstanceEdit:444580] Jupe, S, 2009-10-23
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:444617] Jupe, S, 2009-10-26
edited	[InstanceEdit:532507] Jupe, S, 2010-03-01
input	[DefinedSet:444736] pH sensing receptors [plasma membrane] [Homo sapiens] [SimpleEntity:351626] H+ [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:444741] Proton-sensing G-protein-coupled receptors [LiteratureReference:444608] Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms [LiteratureReference:444721] TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor [LiteratureReference:444674] G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine
modified	[InstanceEdit:532503] Jupe, S, 2010-03-01 [InstanceEdit:532504] Jupe, S, 2010-03-01 [InstanceEdit:532571] Jupe, S, 2010-03-01 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors
output	[Complex:444739] pH sensing receptors:H+ [plasma membrane] [Homo sapiens]
releaseDate	2010-03-16
reviewed	[InstanceEdit:450112] D'Eustachio, P, 2009-12-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105838] R-HSA-444731.2
summation	[Summation:444678] The subfamily of G protein-coupled receptors comprising GPR4...
(hasEvent)	[Pathway:373076] Class A/1 (Rhodopsin-like receptors) [Homo sapiens]
(precedingEvent)	[Reaction:749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq [Homo sapiens]
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No pathways have been reviewed or authored by GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (444731)