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Details on Person FPRL2 is activated by the neuroprotective peptide humanin, a...

Class:Id	Summation:444542
_displayName	FPRL2 is activated by the neuroprotective peptide humanin, a...
_timestamp	2009-10-23 16:29:41
created	[InstanceEdit:444492] Jupe, S, 2009-10-23
literatureReference	[LiteratureReference:444541] Identification and characterization of an endogenous chemotactic ligand specific for FPRL2 [LiteratureReference:444490] Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor [LiteratureReference:444530] Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses [LiteratureReference:444525] Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor
text	FPRL2 is activated by the neuroprotective peptide humanin, also an agonist of FPRL1. The peptide F2L is the only reported specific agonist of FPRL2. This is an N-terminal fragment of heme-binding protein. The mechanism of cleavage and secretion of F2L is unknown.
(summation)	[Reaction:444476] FPRL2 receptor binds a wide range of ligands [Homo sapiens]
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