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Details on Person NMDA receptors require binding of two ligands: agonist, glut...

Class:IdSummation:444283
_displayNameNMDA receptors require binding of two ligands: agonist, glut...
_timestamp2018-11-07 20:14:03
created[InstanceEdit:444282] Mahajan, SS, 2009-10-23
literatureReference[LiteratureReference:9614329] Kinetic analysis of antagonist action at N-methyl-D-aspartic acid receptors. Two binding sites each for glutamate and glycine
[LiteratureReference:9610058] Subunit arrangement and function in NMDA receptors
[LiteratureReference:9627651] Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes
modified[InstanceEdit:444379] Mahajan, SS, 2009-10-23
[InstanceEdit:9611654] Orlic-Milacic, Marija, 2018-06-18
[InstanceEdit:9614333] Orlic-Milacic, Marija, 2018-07-24
[InstanceEdit:9614338] Orlic-Milacic, Marija, 2018-07-24
[InstanceEdit:9627650] Orlic-Milacic, Marija, 2018-11-02
[InstanceEdit:9627655] Orlic-Milacic, Marija, 2018-11-02
[InstanceEdit:9628316] Orlic-Milacic, Marija, 2018-11-07
textNMDA receptors require binding of two ligands: agonist, glutamate and co-agonist, glycine or D-serine. The extracellular ligand binding domain in GluN1 (GRIN1, NR1) subunits binds co-agonist glycine or D-serine and the extracellular ligand binding domain in GluN2 (GRIN2, NR2) binds glutamate. In total, two molecules of glycine or D-serine (one for each of the two GluN1 subunits) and two molecules of glutamate (one for each of the two GluN2 subunits) are bound to activate one NMDA receptor (Kleckner and Dingledine 1988, Benveniste and Mayer 1991, Furukawa et al. 2005).
(summation)[Reaction:432172] Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor [Homo sapiens]
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