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Details on Person VMAT1/2 can mediate the transport of biogenic amines

Class:IdReaction:444160
_displayNameVMAT1/2 can mediate the transport of biogenic amines
_doReleaseTRUE
_timestamp2025-11-07 17:19:21
authored[InstanceEdit:444157] Jassal, Bijay, 2009-10-22
catalystActivity[CatalystActivity:444156] monoamine transmembrane transporter activity of VMAT1/2 [clathrin-sculpted monoamine transport vesicle membrane]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:444157] Jassal, Bijay, 2009-10-22
crossReference[DatabaseIdentifier:9956826] RHEA:73745
[DatabaseIdentifier:9956835] RHEA:73749
[DatabaseIdentifier:9956820] RHEA:73741
edited[InstanceEdit:433105] Jassal, Bijay, 2009-08-21
input[DefinedSet:444154] Biogenic amines transported by VMAT1/2 [cytosol]
[SimpleEntity:374900] H+ [clathrin-sculpted monoamine transport vesicle lumen]
[SimpleEntity:374900] H+ [clathrin-sculpted monoamine transport vesicle lumen]
internalReviewed[InstanceEdit:9971584] D'Eustachio, Peter, 2025-11-07
isChimericFALSE
literatureReference[LiteratureReference:444155] Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter
[LiteratureReference:444158] Functional identification and molecular cloning of a human brain vesicle monoamine transporter
[LiteratureReference:9956834] Structural insights into vesicular monoamine storage and drug interactions
modified[InstanceEdit:446288] Jassal, Bijay, 2009-11-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9956833] Stephan, Ralf, 2025-06-14
[InstanceEdit:9971585] D'Eustachio, Peter, 2025-11-07
[InstanceEdit:9971589] D'Eustachio, Peter, 2025-11-07
nameVMAT1/2 can mediate the transport of biogenic amines
output[DefinedSet:444152] Biogenic amines transported by VMAT1/2 [clathrin-sculpted monoamine transport vesicle lumen]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2009-12-15
reviewed[InstanceEdit:446289] He, Lei, 2009-11-12
[InstanceEdit:9971588] D'Eustachio, Peter, 2025-11-07
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104069] R-HSA-444160.2
structureModified[InstanceEdit:9956833] Stephan, Ralf, 2025-06-14
summation[Summation:444161] The human gene SLC18A1 encodes the vesicular monoamine trans...
(replacementInstances)[_Deleted:446280] Deletion of instance: 444113
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No pathways have been reviewed or authored by VMAT1/2 can mediate the transport of biogenic amines (444160)