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Details on Person SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol

Class:IdReaction:444120
_displayNameSLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol
_doReleaseTRUE
_timestamp2015-01-07 17:17:31
authored[InstanceEdit:444106] Jassal, Bijay, 2009-10-22
catalystActivity[CatalystActivity:444119] glycine:sodium symporter activity of SLC6A5,9 [plasma membrane]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:444106] Jassal, Bijay, 2009-10-22
edited[InstanceEdit:433105] Jassal, Bijay, 2009-08-21
input[SimpleEntity:266029] Gly [extracellular region]
[SimpleEntity:188972] Cl- [extracellular region]
[SimpleEntity:74113] Na+ [extracellular region]
isChimericFALSE
literatureReference[LiteratureReference:444138] Molecular cloning and functional expression of the human glycine transporter GlyT2 and chromosomal localisation of the gene in the human genome
[LiteratureReference:444097] Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes
[LiteratureReference:444103] Mutations in the gene encoding GlyT2 (SLC6A5) define a presynaptic component of human startle disease
modified[InstanceEdit:446288] Jassal, Bijay, 2009-11-12
[InstanceEdit:5660943] Jassal, Bijay, 2015-01-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameSLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol
output[SimpleEntity:29424] Gly [cytosol]
[SimpleEntity:352022] Cl- [cytosol]
[SimpleEntity:83910] Na+ [cytosol]
releaseDate2009-12-15
reviewed[InstanceEdit:446289] He, Lei, 2009-11-12
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104575] R-HSA-444120.2
summation[Summation:444089] The amino acid glycine plays an important role in neurotrans...
(hasEvent)[Pathway:442660] SLC-mediated transport of neurotransmitters [Homo sapiens]
(normalReaction)[FailedReaction:5660840] Defective SLC6A5 does not cotransport Gly, Cl-, Na+ from extracellular region to cytosol [Homo sapiens]
(precedingEvent)[Reaction:428625] Vesicular inhibitory amino acid transport [Homo sapiens]
(updatedInstance)[_UpdateTracker:9785021] Update Tracker - [Reaction:444120] SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol - v52:[modifyText]
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