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Details on Person p38 MAPK alpha does not have a nuclear export signal (NES) a...
| Class:Id | Summation:444071 |
|---|---|
| _displayName | p38 MAPK alpha does not have a nuclear export signal (NES) a... |
| _timestamp | 2012-11-16 09:49:25 |
| created | [InstanceEdit:444069] Shamovsky, V, 2009-10-20 |
| literatureReference | [LiteratureReference:442896] Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export |
| modified | [InstanceEdit:452185] Shamovsky, V, 2010-01-15 [InstanceEdit:975771] Shamovsky, V, 2010-10-04 [InstanceEdit:977264] D'Eustachio, P, 2010-10-15 [InstanceEdit:2586716] Shamovsky, V, 2012-11-16 |
| text | p38 MAPK alpha does not have a nuclear export signal (NES) and cannot leave the nucleus by itself, but rather needs to be associated with MAP kinase-activated protein kinase 2 (MAPKAPK2 or MK2). The NES of MAPKAPK2 facilitates the transport of both kinases from the nucleus to the cytoplasm but only after MK2 has been phosphorylated by p38alpha. p38 MAPK alpha phosphorylates MK2 at Thr222, Ser272, and Thr334. The phosphorylation of Thr334 but not the kinase activity of MK2 has been demonstrated to be critical for the nuclear export of the p38 alpha - MK2 complex. Phosphorylation of Thr334 is believed to induce a conformational change in the complex exposing NES prior to interaction with the leptomycin B-sensitive nuclear export receptor. |
| (summation) | [Reaction:442862] Nuclear export of p38 MAPK mediated by its substrate MAPKAPK2 or 3 [Gallus gallus] [Reaction:450257] Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 [Homo sapiens] |
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