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Details on Person SLC6A2 cotransports NAd, Na+,Cl- from extracellular region to cytosol

Class:Id	Reaction:443997
_displayName	SLC6A2 cotransports NAd, Na+,Cl- from extracellular region to cytosol
_doRelease	TRUE
_timestamp	2025-08-13 17:18:13
authored	[InstanceEdit:444041] Jassal, Bijay, 2009-10-20
catalystActivity	[CatalystActivity:444029] norepinephrine:sodium symporter activity of SLC6A2 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:444041] Jassal, Bijay, 2009-10-20
crossReference	[DatabaseIdentifier:9956803] RHEA:70924
edited	[InstanceEdit:433105] Jassal, Bijay, 2009-08-21
input	[SimpleEntity:374935] NAd [extracellular region] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:188972] Cl- [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:444019] Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter [LiteratureReference:444000] Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency [LiteratureReference:9956809] Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence
modified	[InstanceEdit:446288] Jassal, Bijay, 2009-11-12 [InstanceEdit:5660699] Jassal, Bijay, 2015-01-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9956811] Stephan, Ralf, 2025-06-14 [InstanceEdit:9963146] Stephan, Ralf, 2025-08-13
name	SLC6A2 cotransports NAd, Na+,Cl- from extracellular region to cytosol NAT1 mediates norepinephrine uptake
output	[SimpleEntity:209789] NAd [cytosol] [SimpleEntity:83910] Na+ [cytosol] [SimpleEntity:352022] Cl- [cytosol]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2009-12-15
reviewed	[InstanceEdit:446289] He, Lei, 2009-11-12 [InstanceEdit:9962967] D'Eustachio, Peter, 2025-08-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105974] R-HSA-443997.3
structureModified	[InstanceEdit:9956811] Stephan, Ralf, 2025-06-14
summation	[Summation:443993] Noradrenaline (NAd, norepinephrine) is a neurotransmitter wh...
(hasEvent)	[Pathway:442660] SLC-mediated transport of neurotransmitters [Homo sapiens]
(normalReaction)	[FailedReaction:5659764] Defective SLC6A2 does not cotransport NAd, Na+ from extracellular region to cytosol [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785242] Update Tracker - [Reaction:443997] SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol - v52:[modifyText] [_UpdateTracker:9964634] Update Tracker - [Reaction:443997] SLC6A2 cotransports NAd, Na+,Cl- from extracellular region to cytosol - v94:[modifyText, removeInput, removeLiteratureReference, removeOutput]
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