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Details on Person Close homolog of L1 (CHL1), associates with Contactin-6/NB-3...
| Class:Id | Summation:443571 |
|---|---|
| _displayName | Close homolog of L1 (CHL1), associates with Contactin-6/NB-3... |
| _timestamp | 2009-12-30 21:52:14 |
| created | [InstanceEdit:443547] Garapati, P V, 2009-10-09 |
| literatureReference | [LiteratureReference:419030] L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth |
| modified | [InstanceEdit:444909] Garapati, P V, 2009-10-27 [InstanceEdit:451256] Garapati, P V, 2009-12-30 |
| text | Close homolog of L1 (CHL1), associates with Contactin-6/NB-3, a member of the F3/contactin family of neural recognition molecules, and enhances its cell surface expression. CHL1 and NB3 may engage in a cis-interaction and form a coreceptor/adhesion complex on the neuronal surface. CHL1/NB3 clustering activates protein tyrosine phosphatase alpha (PTP alpha), which dephosphorylates and activates Fyn. Both PTP alpha and Fyn are required for proper apical dendrite orientation of deep layer pyramidal neurons. |
| (summation) | [Reaction:443777] CHL1 interacts with contactin-6 [Mus musculus] [Reaction:443782] CHL1 interacts with contactin-6 [Homo sapiens] |
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No pathways have been reviewed or authored by Close homolog of L1 (CHL1), associates with Contactin-6/NB-3... (443571)
