Query author contributions in Reactome
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Details on Person Numb is thought to be a phosphotyrosine binding (PTB) domain...
| Class:Id | Summation:443549 |
|---|---|
| _displayName | Numb is thought to be a phosphotyrosine binding (PTB) domain... |
| _timestamp | 2009-11-19 21:02:29 |
| created | [InstanceEdit:443547] Garapati, P V, 2009-10-09 |
| modified | [InstanceEdit:444909] Garapati, P V, 2009-10-27 [InstanceEdit:447049] Garapati, P V, 2009-11-19 |
| text | Numb is thought to be a phosphotyrosine binding (PTB) domain containing cargo specific adaptor protein, which links specific cargo to the endocytic machinery. It associates with collapsin response mediator protein-2 (CRMP 2) with its PTB domain and alpha adaptin (a subunit of the AP 2 adaptor complex) through its tripeptide Asp-Pro-Phe (DPF) motif, and is involved in clathrin dependent endocytosis at the plasma membrane. Numb is associated with L1 under physiological conditions and functions in endocytosis of L1 in the C domain membrane of axonal growth cones. |
| (summation) | [Reaction:443783] Interaction of NUMB with L1 [Homo sapiens] |
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No pathways have been reviewed or authored by Numb is thought to be a phosphotyrosine binding (PTB) domain... (443549)
