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Details on Person Resting platelets contain a heterotrimeric complex of GPIb-I...

Class:IdSummation:443405
_displayNameResting platelets contain a heterotrimeric complex of GPIb-I...
_timestamp2009-10-06 09:56:08
created[InstanceEdit:443417] Jupe, S, 2009-10-06
literatureReference[LiteratureReference:443424] Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3zeta
[LiteratureReference:443436] Platelet GPIb-IX-V-dependent signaling
textResting platelets contain a heterotrimeric complex of GPIb-IX-V, 14-3-3-zeta and the p85 subunit of PI-3K. While GPIb-IX-V has no apparent binding sites for PI3K so the interaction with p85 is likely to be mediated by 14-3-3-zeta.
(summation)[Reaction:443402] GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K [Homo sapiens]
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