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Details on Person Grb2:SOS1 complex binds to phosphorylated Shp2

Class:IdReaction:443357
_displayNameGrb2:SOS1 complex binds to phosphorylated Shp2
_timestamp2016-07-15 23:49:27
authored[InstanceEdit:443152] Williams, MG, 2009-10-02
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:443210] Williams, MG, 2009-10-02
figure[Figure:443106] /figures/DrosFGFRA11.jpg
input[Complex:443341] FGF1:Phospho (7 sites) FGFR1:Phospho FRS2 dimer complex:Phospho Shp2 [plasma membrane] [Mus musculus]
[Complex:443296] Grb2:SOS1 [cytosol] [Mus musculus]
isChimericFALSE
literatureReference[LiteratureReference:443100] Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
modified[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:8879177] Wu, G, 2016-07-15
nameGrb2:SOS1 complex binds to phosphorylated Shp2
output[Complex:443362] FGF1:Phospho (7 sites) FGFR1:Phospho FRS2 dimer complex:Phospho Shp2:Grb2:SOS1 [plasma membrane] [Mus musculus]
species[Species:48892] Mus musculus
stableIdentifier[StableIdentifier:8895580] R-MMU-443357.1
summation[Summation:443150] In mice, phosphorylated Tyr546 of the protein tyrosine phosp...
(hasEvent)[Pathway:443182] FGFR pathway - Inferred Events
(inferredFrom)[Reaction:443199] DRK:SOS complex binds to phosphorylated CSW (FGFR) [Drosophila melanogaster]
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