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Details on Person FGFR1 dimer complex autophosphorylates and is activated

Class:IdReaction:443353
_displayNameFGFR1 dimer complex autophosphorylates and is activated
_timestamp2016-07-15 23:49:56
authored[InstanceEdit:443152] Williams, MG, 2009-10-02
catalystActivity[CatalystActivity:443354] protein tyrosine kinase activity of FGFR1c [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:443210] Williams, MG, 2009-10-02
figure[Figure:443134] /figures/DrosFGFRA04.jpg
input[Complex:443083] FGF1:FGFR1 dimer complex [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:190942] Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction
[LiteratureReference:201396] Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors
[LiteratureReference:443277] Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction
modified[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:8879177] Wu, G, 2016-07-15
nameFGFR1 dimer complex autophosphorylates and is activated
output[Complex:443322] FGF1:Phospho (7 sites) FGFR1 dimer complex [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8907758] R-HSA-443353.1
summation[Summation:443335] In humans, the dimerised fibroblast growth factor receptor 1...
(hasEvent)[Pathway:443182] FGFR pathway - Inferred Events
(inferredFrom)[Reaction:443260] FGFR dimer complex autphosphorylates and is activated [Drosophila melanogaster]
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