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Details on Person FGF ligands bind to FGFR dimer extracellular domains

Class:Id	Reaction:443257
_displayName	FGF ligands bind to FGFR dimer extracellular domains
_doRelease	FALSE
_timestamp	2017-06-27 17:35:50
authored	[InstanceEdit:443152] Williams, MG, 2009-10-02
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:443210] Williams, MG, 2009-10-02
figure	[Figure:443360] /figures/DrosFGFRA02.jpg
input	[DefinedSet:443186] FGF [extracellular region] [Drosophila melanogaster] [DefinedSet:443186] FGF [extracellular region] [Drosophila melanogaster] [Complex:443285] FGFR:STUMPS [plasma membrane] [Drosophila melanogaster] [Complex:443285] FGFR:STUMPS [plasma membrane] [Drosophila melanogaster] [DefinedSet:206547] HSPG [plasma membrane] [Drosophila melanogaster] [SimpleEntity:190915] HS [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:443271] FGF ligands in Drosophila have distinct activities required to support cell migration and differentiation [LiteratureReference:443264] Drosophila glypican Dally-like acts in FGF-receiving cells to modulate FGF signaling during tracheal morphogenesis [LiteratureReference:443163] FGF8-like1 and FGF8-like2 encode putative ligands of the FGF receptor Htl and are required for mesoderm migration in the Drosophila gastrula [LiteratureReference:443233] pyramus and thisbe: FGF genes that pattern the mesoderm of Drosophila embryos [LiteratureReference:443118] branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching [LiteratureReference:443206] Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin [LiteratureReference:443238] Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization
modified	[InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9010639] D'Eustachio, Peter, 2017-06-27
name	FGF ligands bind to FGFR dimer extracellular domains
output	[Complex:443219] FGF:FGFR:STUMPS dimer complex [plasma membrane] [Drosophila melanogaster] [DefinedSet:206547] HSPG [plasma membrane] [Drosophila melanogaster]
precedingEvent	[Reaction:443222] STUMPS binds to FGFR cytoplasmic domain [Drosophila melanogaster]
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8902717] R-DME-443257.1
summation	[Summation:443267] The fibroblast growth factor (FGF) ligand Branchless (BNL) b...
(hasEvent)	[Pathway:443263] Assembly of the FGFR complex [Drosophila melanogaster]
(precedingEvent)	[Reaction:443260] FGFR dimer complex autphosphorylates and is activated [Drosophila melanogaster]
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No pathways have been reviewed or authored by FGF ligands bind to FGFR dimer extracellular domains (443257)