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Details on Person Activated FGFR1 dimer complex phosphorylates Shp2

Class:Id	Reaction:443252
_displayName	Activated FGFR1 dimer complex phosphorylates Shp2
_timestamp	2016-07-15 23:49:38
authored	[InstanceEdit:443152] Williams, MG, 2009-10-02
catalystActivity	[CatalystActivity:443198] protein tyrosine kinase activity of Phospho (7 sites) FGFR1 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:443210] Williams, MG, 2009-10-02
figure	[Figure:443349] /figures/DrosFGFRA08.jpg
input	[Complex:443181] FGF1:Phospho (7 sites) FGFR1:Phospho FRS2 dimer complex:Shp2 [plasma membrane] [Mus musculus] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:443100] Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation [LiteratureReference:443188] Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras [LiteratureReference:443265] The adaptor function of SHP-2 downstream of the prolactin receptor is required for the recruitment of p29, a substrate of SHP-2
modified	[InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	Activated FGFR1 dimer complex phosphorylates Shp2
output	[Complex:443341] FGF1:Phospho (7 sites) FGFR1:Phospho FRS2 dimer complex:Phospho Shp2 [plasma membrane] [Mus musculus] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:8899972] R-MMU-443252.1
summation	[Summation:443225] In mice, the protein tyrosine phosphatase adaptor protein, S...
(hasEvent)	[Pathway:443182] FGFR pathway - Inferred Events
(inferredFrom)	[Reaction:443295] Activated FGFR dimer complex phosphorylates CSW [Drosophila melanogaster]
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