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Details on Person Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

Class:IdLiteratureReference:443100
_displayNameBinding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
_timestamp2009-10-02 13:47:08
author[Person:182115] Hadari, YR
[Person:189831] Kouhara, H
[Person:182118] Lax, I
[Person:179800] Schlessinger, J
created[InstanceEdit:443210] Williams, MG, 2009-10-02
journalMol Cell Biol
pages3966-73
pubMedIdentifier9632781
titleBinding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
volume18
year1998
(literatureReference)[Summation:1268151] p-FRS2 has two PPTN11/SHP2-binding sites at pY436 and pY471.
[Reaction:443252] Activated FGFR1 dimer complex phosphorylates Shp2 [Mus musculus]
[Reaction:443357] Grb2:SOS1 complex binds to phosphorylated Shp2 [Mus musculus]
[Reaction:5654397] Activated FGFR2 phosphorylates FRS2 [Homo sapiens]
[Reaction:5654408] Activated FGFR3 phosphorylates FRS2 [Homo sapiens]
[Reaction:5654418] Activated FGFR4 phosphorylates FRS2 [Homo sapiens]
[Reaction:5654575] Activated FGFR1 phosphorylates FRS2 [Homo sapiens]
[Reaction:5654584] Activated FGFR1:p-FRS bind to PPTN11 [Homo sapiens]
[Reaction:5654592] Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 [Homo sapiens]
[Reaction:5654594] Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 [Homo sapiens]
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