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Details on Person activated MAPK3/MAPK6 migrates to nucleus

Class:Id	Reaction:442938
_displayName	activated MAPK3/MAPK6 migrates to nucleus
_doRelease	TRUE
_timestamp	2010-12-02 14:36:53
authored	[InstanceEdit:438031] Shamovsky, V, 2009-09-22
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm [Compartment:13231] nuclear envelope
created	[InstanceEdit:442879] Shamovsky, V, 2009-09-29
edited	[InstanceEdit:668815] Shamovsky, V, 2010-05-04
inferredFrom	[Reaction:450296] Phosphorylated MKK3/MKK6 migrates to nucleus [Homo sapiens]
input	[CandidateSet:437977] phospho MKK3/ phospho MKK6 [cytosol] [Gallus gallus]
literatureReference	[LiteratureReference:442901] Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine [LiteratureReference:442922] Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2
modified	[InstanceEdit:446261] Shamovsky, V, 2009-11-11 [InstanceEdit:571391] Shamovsky, V, 2010-04-09 [InstanceEdit:674748] Shamovsky, V, 2010-05-05 [InstanceEdit:680257] Shamovsky, V, 2010-05-05 [InstanceEdit:749441] Shamovsky, V, 2010-05-18 [InstanceEdit:796987] Shamovsky, V, 2010-05-24 [InstanceEdit:844697] Shamovsky, V, 2010-05-28 [InstanceEdit:1004540] D'Eustachio, P, 2010-11-09 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	activated MAPK3/MAPK6 migrates to nucleus
output	[CandidateSet:442940] phospho MKK3/ phospho MKK6 [nucleoplasm] [Gallus gallus]
precedingEvent	[Reaction:437984] Phosphorylation of MKK3/MKK6 by activated TAK1 [Gallus gallus] [Reaction:433957] Activation of recruited TAK1 [Gallus gallus] [Reaction:451447] Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 [Gallus gallus]
releaseDate	2010-12-14
reviewed	[InstanceEdit:789693] D'Eustachio, P, 2010-05-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1104963] R-GGA-442938.2
summation	[Summation:444070] The p38 activators MKK3 (MAP2K3) and MKK6 (MAP2K6) were pres...
(hasEvent)	[Pathway:437980] Activated TAK1 mediates p38 MAP kinase phosphorylation [Gallus gallus]
(precedingEvent)	[Reaction:438019] activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 [Gallus gallus]
(updatedInstance)	[_UpdateTracker:9779820] Update Tracker - [Reaction:442938] activated MAPK3/MAPK6 migrates to nucleus - v64:[modifyText]
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