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Details on Person Active p38 MAPK phosphorylates MAPKAPK2 or 3

Class:Id	Reaction:442913
_displayName	Active p38 MAPK phosphorylates MAPKAPK2 or 3
_doRelease	TRUE
_timestamp	2010-12-02 14:34:40
authored	[InstanceEdit:438031] Shamovsky, V, 2009-09-22
catalystActivity	[CatalystActivity:442864] protein serine/threonine/tyrosine kinase activity of phospho -p38 MAPK : MAPKAPK 2 or MAPKAPK3 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:442879] Shamovsky, V, 2009-09-29
edited	[InstanceEdit:668815] Shamovsky, V, 2010-05-04
inferredFrom	[Reaction:450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 [Homo sapiens]
input	[Complex:442905] phospho -p38 MAPK : MAPKAPK 2 or MAPKAPK3 [nucleoplasm] [Gallus gallus] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm]
literatureReference	[LiteratureReference:187736] Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2 [LiteratureReference:442952] Molecular basis of MAPK-activated protein kinase 2:p38 assembly [LiteratureReference:442929] Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer [LiteratureReference:442930] Catalysis and function of the p38 alpha.MK2a signaling complex
modified	[InstanceEdit:446249] Shamovsky, V, 2009-11-11 [InstanceEdit:451539] Shamovsky, V, 2010-01-05 [InstanceEdit:571307] Shamovsky, V, 2010-04-09 [InstanceEdit:674712] Shamovsky, V, 2010-05-05 [InstanceEdit:680254] Shamovsky, V, 2010-05-05 [InstanceEdit:796980] Shamovsky, V, 2010-05-24 [InstanceEdit:844693] Shamovsky, V, 2010-05-28 [InstanceEdit:1004540] D'Eustachio, P, 2010-11-09 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Active p38 MAPK phosphorylates MAPKAPK2 or 3
output	[SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [Complex:442915] phospho -p38 MAPK : phospho- MAPKAPK 2 or phospho MAPKAPK3 [nucleoplasm] [Gallus gallus]
precedingEvent	[Reaction:438019] activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 [Gallus gallus] [Reaction:442938] activated MAPK3/MAPK6 migrates to nucleus [Gallus gallus]
regulatedBy	[NegativeRegulation:442897] Negative regulation by 'MAPK phosphatases [nucleoplasm]'
releaseDate	2010-12-14
reviewed	[InstanceEdit:789693] D'Eustachio, P, 2010-05-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1104564] R-GGA-442913.3
summation	[Summation:444067] Human p38 MAPK alpha forms a complex with MK2 even when the ...
(hasEvent)	[Pathway:437980] Activated TAK1 mediates p38 MAP kinase phosphorylation [Gallus gallus]
(precedingEvent)	[Reaction:442862] Nuclear export of p38 MAPK mediated by its substrate MAPKAPK2 or 3 [Gallus gallus]
(updatedInstance)	[_UpdateTracker:9787008] Update Tracker - [Reaction:442913] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - v46:[modifyText]
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