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Details on Person PAK phosphorylates cortactin

Class:IdReaction:442832
_displayNamePAK phosphorylates cortactin
_doReleaseTRUE
_timestamp2017-03-15 15:32:35
authored[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
[InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
catalystActivity[CatalystActivity:442840] protein serine/threonine kinase activity of p-S,T-PAK1,2,3 [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:442837] Jupe, S, 2009-09-29
edited[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
inferredFrom
input[EntityWithAccessionedSequence:201894] CTTN [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:442838] Phosphorylation of cortactin by p21-activated kinase
[LiteratureReference:5669227] A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly
[LiteratureReference:442542] Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin
[LiteratureReference:443872] Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1
[LiteratureReference:5669213] Pak1 phosphorylation enhances cortactin-N-WASP interaction in clathrin-caveolin-independent endocytosis
modified[InstanceEdit:5669229] Orlic-Milacic, Marija, 2015-01-30
[InstanceEdit:5674244] Orlic-Milacic, Marija, 2015-02-11
[InstanceEdit:5674554] Orlic-Milacic, Marija, 2015-02-12
[InstanceEdit:5674621] Orlic-Milacic, Marija, 2015-02-13
[InstanceEdit:8981942] Orlic-Milacic, Marija, 2017-03-15
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePAK phosphorylates cortactin
output[EntityWithAccessionedSequence:442842] p-S113-CTTN [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2015-03-19
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5680111] R-HSA-442832.3
summation[Summation:442835] PAKs can associate with cortactin (CTTN), a cortical actin b...
(hasEvent)[Pathway:419233] Cytoskeletal regulation [Homo sapiens]
[Pathway:5627123] RHO GTPases activate PAKs [Homo sapiens]
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