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Details on Person WASPs or WAVEs activate the ARP2/3 complex

Class:Id	Reaction:442592
_displayName	WASPs or WAVEs activate the ARP2/3 complex
_doRelease	TRUE
_timestamp	2020-02-06 10:19:50
authored	[InstanceEdit:434636] Jupe, S, 2009-09-02
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:442541] Jupe, S, 2009-09-28
edited	[InstanceEdit:2029483] Garapati, P V, 2012-01-04 [InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
inferredFrom	[Reaction:442561] WASP/N-WASP activate the Arp2/3 complex [Rattus norvegicus]
input	[Complex:1861670] ARP2/3 complex (ATP bound) [cytosol] [Homo sapiens] [DefinedSet:2197675] WAVE2, WASP, N-WASP [plasma membrane] [Homo sapiens] [Complex:201857] G-actin [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:442576] Different WASP family proteins stimulate different Arp2/3 complex-dependent actin-nucleating activities [LiteratureReference:2197700] WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement
modified	[InstanceEdit:870421] Jupe, S, 2010-06-08 [InstanceEdit:2029462] Garapati, P V, 2012-01-04 [InstanceEdit:2197699] Garapati, P V, 2012-04-13 [InstanceEdit:2248843] Garapati, P V, 2012-05-14 [InstanceEdit:2263488] Garapati, P V, 2012-05-21 [InstanceEdit:2272655] Garapati, P V, 2012-05-25 [InstanceEdit:2429700] Garapati, P V, 2012-08-09 [InstanceEdit:2457636] Garapati, P V, 2012-08-27 [InstanceEdit:3132781] Garapati, P V, 2013-02-13 [InstanceEdit:5672641] Orlic-Milacic, Marija, 2015-02-05 [InstanceEdit:5672737] Orlic-Milacic, Marija, 2015-02-06 [InstanceEdit:5672738] Orlic-Milacic, Marija, 2015-02-06 [InstanceEdit:5674559] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9673434] Murillo, Julieth, 2020-01-07 [InstanceEdit:9675994] Murillo, Julieth, 2020-02-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	WASPs or WAVEs activate the ARP2/3 complex
output	[Complex:442565] WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] [Homo sapiens]
precedingEvent	[Reaction:430180] NCK recruits WASP [Homo sapiens] [Reaction:2197698] Src phosphorylate WASP,N-WASP [Homo sapiens] [Reaction:2197691] WIP binds WASP,N-WASP, activating them [Homo sapiens] [Reaction:2130194] ABL phosphorylates WAVEs [Homo sapiens] [Reaction:2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) [Homo sapiens]
releaseDate	2013-03-12
reviewed	[InstanceEdit:2248842] Rosales, C, 2012-05-14 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200264] R-HSA-442592.3
summation	[Summation:2028887] Once WASPs (WASP and N-WASP) and WAVEs (WAVE2 and probably W...
(hasEvent)	[Pathway:419233] Cytoskeletal regulation [Homo sapiens] [Pathway:2029482] Regulation of actin dynamics for phagocytic cup formation [Homo sapiens] [Pathway:5663213] RHO GTPases Activate WASPs and WAVEs [Homo sapiens] [Pathway:9664422] FCGR3A-mediated phagocytosis [Homo sapiens]
(precedingEvent)	[Reaction:2029466] (WASPs, WAVE):G-actin:ARP2/3 binds F-actin [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785376] Update Tracker - [Reaction:442592] WASPs or WAVEs activate the ARP2/3 complex - v52:[modifyText]
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