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Details on Person Activation of WASP and N-WASP by CDC42

Class:Id	Reaction:442572
_displayName	Activation of WASP and N-WASP by CDC42
_doRelease	TRUE
_timestamp	2020-01-07 13:42:59
authored	[InstanceEdit:2029483] Garapati, P V, 2012-01-04
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:442541] Jupe, S, 2009-09-28
edited	[InstanceEdit:2029483] Garapati, P V, 2012-01-04 [InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
input	[Complex:448879] Cdc42:GTP [plasma membrane] [Mus musculus] [SimpleEntity:179856] PI(4,5)P2 [plasma membrane] [DefinedSet:2029096] Wasp/N-Wasp [cytosol] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:2028921] Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP [LiteratureReference:442552] The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly [LiteratureReference:442550] Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42 [LiteratureReference:442590] Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization
modified	[InstanceEdit:870421] Jupe, S, 2010-06-08 [InstanceEdit:2029447] Garapati, P V, 2012-01-04 [InstanceEdit:2263488] Garapati, P V, 2012-05-21 [InstanceEdit:2272655] Garapati, P V, 2012-05-25 [InstanceEdit:2429700] Garapati, P V, 2012-08-09 [InstanceEdit:2457636] Garapati, P V, 2012-08-27 [InstanceEdit:3132781] Garapati, P V, 2013-02-13 [InstanceEdit:5672396] Orlic-Milacic, Marija, 2015-02-05 [InstanceEdit:5674559] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9673432] Murillo, Julieth, 2020-01-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activation of WASP and N-WASP by CDC42
output	[Complex:2029162] Cdc42-GTP:Wasp/N-Wasp [cytosol] [Mus musculus]
releaseDate	2013-03-12
reviewed	[InstanceEdit:2248842] Rosales, C, 2012-05-14 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:3200192] R-MMU-442572.3
summation	[Summation:5672395] The activation of WASP and N-WASP (WASL) by CDC42:GTP was de...
(inferredFrom)	[Reaction:442586] Activation of WASP and N-WASP by CDC42 [Homo sapiens] [Reaction:9670155] CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784993] Update Tracker - [Reaction:442572] Activation of WASP and N-WASP by CDC42 - v52:[add_removeSummation]
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