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Details on Person Translocation of cortactin to the cell periphery is mediated...

Class:IdSummation:442563
_displayNameTranslocation of cortactin to the cell periphery is mediated...
_timestamp2009-10-14 12:12:44
created[InstanceEdit:442541] Jupe, S, 2009-09-28
literatureReference[LiteratureReference:443872] Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1
[LiteratureReference:442557] Inducible phosphorylation of cortactin is not necessary for cortactin-mediated actin polymerisation
[LiteratureReference:442542] Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin
[LiteratureReference:443883] Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton
modified[InstanceEdit:443885] Jupe, S, 2009-10-14
textTranslocation of cortactin to the cell periphery is mediated by the activation of Rac1. The mechanism for this is unclear; phosphorylation of cortactin by several kinases including Src, Syk, Erk and PAK has been suggested to link Rac1 to cortactin translocation but this is controversial. The phosphorylation state of cortactin may not influence translocation but instead regulate its interactions with actin.
(summation)[BlackBoxEvent:442571] Rac1 mediated translocation of cortactin to cell periphery [Homo sapiens]
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