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Details on Person In mouse 3T3-L1 cells, the PPARG:RXRA heterodimer binds spec...
| Class:Id | Summation:442523 |
|---|---|
| _displayName | In mouse 3T3-L1 cells, the PPARG:RXRA heterodimer binds spec... |
| _timestamp | 2010-11-15 04:18:29 |
| created | [InstanceEdit:442522] May, B, 2009-09-27 |
| modified | [InstanceEdit:442525] May, B, 2009-09-27 [InstanceEdit:1014259] May, B, 2010-11-15 |
| text | In mouse 3T3-L1 cells, the PPARG:RXRA heterodimer binds specific the PPRE element, two 6-bp DR-1 motifs separated by 1 nucleotide, in the promoters of target genes such as aP2/Fabp4 even in the absence of fatty acid ligands that activate PPARG (IJpenberg et al. 1997, Okuno et al. 2001). When activating ligands of PPARG are absent PPARG:RXRA recruits corepressors such as Smrt, NCoR, and Hdac33 to maintain the target gene in an inactive state (Tontonoz et al. 1994, Yu et al. 2005, Yoo et al. 2006). |
| (summation) | [Reaction:442515] Pparg:Rxra heterodimer binds to PPARG corepressors [Mus musculus] |
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No pathways have been reviewed or authored by In mouse 3T3-L1 cells, the PPARG:RXRA heterodimer binds spec... (442523)
