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Details on Person SLC39A1-4 transports Zn2+ from extracellular region to cytosol

Class:IdReaction:442422
_displayNameSLC39A1-4 transports Zn2+ from extracellular region to cytosol
_doReleaseTRUE
_timestamp2025-08-13 17:45:33
authored[InstanceEdit:442374] Jassal, Bijay, 2009-09-25
catalystActivity[CatalystActivity:442350] zinc ion transmembrane transporter activity of SLC39A1-4 [plasma membrane]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:442374] Jassal, Bijay, 2009-09-25
crossReference[DatabaseIdentifier:9958440] RHEA:29353
edited[InstanceEdit:433105] Jassal, Bijay, 2009-08-21
input[SimpleEntity:158417] Zn2+ [extracellular region]
isChimericFALSE
literatureReference[LiteratureReference:442365] The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells
[LiteratureReference:442343] Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex
[LiteratureReference:442382] Functional expression of the human hZIP2 zinc transporter
[LiteratureReference:442348] hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands
[LiteratureReference:442418] Evidence for a zinc uptake transporter in human prostate cancer cells which is regulated by prolactin and testosterone
[LiteratureReference:442409] Identification of SLC39A4, a gene involved in acrodermatitis enteropathica
[LiteratureReference:442385] A novel member of a zinc transporter family is defective in acrodermatitis enteropathica
[LiteratureReference:445725] Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression
[LiteratureReference:445722] Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts
modified[InstanceEdit:445733] Jassal, Bijay, 2009-11-05
[InstanceEdit:446288] Jassal, Bijay, 2009-11-12
[InstanceEdit:5654127] Jassal, Bijay, 2014-12-03
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9958441] Stephan, Ralf, 2025-06-20
[InstanceEdit:9963151] Stephan, Ralf, 2025-08-13
nameSLC39A1-4 transports Zn2+ from extracellular region to cytosol
negativePrecedingEvent[NegativePrecedingEvent:9963154] Futile Cycle: ZnT1 mediates the efflux of zinc from the cell
output[SimpleEntity:29426] Zn2+ [cytosol]
releaseDate2009-12-15
reviewed[InstanceEdit:446289] He, Lei, 2009-11-12
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104585] R-HSA-442422.3
summation[Summation:442325] The human gene SLC39A1 encodes the human zinc transporter hZ...
(hasEvent)[Pathway:442380] Zinc influx into cells by the SLC39 gene family [Homo sapiens]
(normalReaction)[FailedReaction:5654125] Defective SLC39A4 does not transport Zn2+ from extracellular region to cytosol [Homo sapiens]
(precedingEvent)[NegativePrecedingEvent:9963162] Futile Cycle: SLC39A1-4 transports Zn2+ from extracellular region to cytosol
[Reaction:435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages [Homo sapiens]
[Reaction:435375] ZnT2 facilitates zinc vesicular sequestration [Homo sapiens]
[Reaction:437084] ZnT3 transports zinc into synaptic vesicles [Homo sapiens]
[Reaction:437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells [Homo sapiens]
[Reaction:437136] SLC30A8 transports Zn2+ from cytosol to secretory granule [Homo sapiens]
[Reaction:437139] ZnT8 transports zinc into the Golgi apparatus [Homo sapiens]
[Reaction:9820566] ZnT5 transports zinc into the golgi apparatus [Homo sapiens]
(updatedInstance)[_UpdateTracker:9785015] Update Tracker - [Reaction:442422] SLC39A1-4 transports Zn2+ from extracellular region to cytosol - v52:[modifyText]
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