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Details on Person ZIP7 mediates zinc efflux from the endoplasmic reticulum

Class:Id	Reaction:442393
_displayName	ZIP7 mediates zinc efflux from the endoplasmic reticulum
_doRelease	TRUE
_timestamp	2025-06-20 08:01:09
authored	[InstanceEdit:442374] Jassal, Bijay, 2009-09-25
catalystActivity	[CatalystActivity:442404] zinc ion transmembrane transporter activity of SLC39A7 [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:442374] Jassal, Bijay, 2009-09-25
crossReference	[DatabaseIdentifier:9958439] RHEA:29352
edited	[InstanceEdit:433105] Jassal, Bijay, 2009-08-21
input	[SimpleEntity:442320] Zn2+ [endoplasmic reticulum lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:442347] Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters
modified	[InstanceEdit:445733] Jassal, Bijay, 2009-11-05 [InstanceEdit:446288] Jassal, Bijay, 2009-11-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9958441] Stephan, Ralf, 2025-06-20
name	ZIP7 mediates zinc efflux from the endoplasmic reticulum
output	[SimpleEntity:29426] Zn2+ [cytosol]
releaseDate	2009-12-15
reviewed	[InstanceEdit:446289] He, Lei, 2009-11-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105565] R-HSA-442393.3
summation	[Summation:442369] The human gene SLC39A7 encodes the zinc transporter ZIP7 (HK...
(hasEvent)	[Pathway:442380] Zinc influx into cells by the SLC39 gene family [Homo sapiens]
(precedingEvent)	[Reaction:435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages [Homo sapiens] [Reaction:435366] ZnT1 mediates the efflux of zinc from the cell [Homo sapiens] [Reaction:435375] ZnT2 facilitates zinc vesicular sequestration [Homo sapiens] [Reaction:437084] ZnT3 transports zinc into synaptic vesicles [Homo sapiens] [Reaction:437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells [Homo sapiens] [Reaction:437136] SLC30A8 transports Zn2+ from cytosol to secretory granule [Homo sapiens] [Reaction:437139] ZnT8 transports zinc into the Golgi apparatus [Homo sapiens] [Reaction:9820566] ZnT5 transports zinc into the golgi apparatus [Homo sapiens]
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No pathways have been reviewed or authored by ZIP7 mediates zinc efflux from the endoplasmic reticulum (442393)