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Details on Person ZIP8 mediates zinc influx into cells

Class:Id	Reaction:442387
_displayName	ZIP8 mediates zinc influx into cells
_doRelease	TRUE
_timestamp	2025-08-13 17:46:08
authored	[InstanceEdit:442374] Jassal, Bijay, 2009-09-25
catalystActivity	[CatalystActivity:442423] zinc ion transmembrane transporter activity of SLC39A8-like proteins [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:442374] Jassal, Bijay, 2009-09-25
crossReference	[DatabaseIdentifier:9958442] RHEA:62253
edited	[InstanceEdit:433105] Jassal, Bijay, 2009-08-21
input	[SimpleEntity:158417] Zn2+ [extracellular region] [SimpleEntity:425425] HCO3- [extracellular region] [SimpleEntity:425425] HCO3- [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:445734] Discovery of ZIP transporters that participate in cadmium damage to testis and kidney [LiteratureReference:446537] The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia [LiteratureReference:3004709] ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties
modified	[InstanceEdit:445733] Jassal, Bijay, 2009-11-05 [InstanceEdit:446288] Jassal, Bijay, 2009-11-12 [InstanceEdit:446536] Jassal, Bijay, 2009-11-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9958441] Stephan, Ralf, 2025-06-20 [InstanceEdit:9963146] Stephan, Ralf, 2025-08-13 [InstanceEdit:9963151] Stephan, Ralf, 2025-08-13
name	ZIP8 mediates zinc influx into cells
negativePrecedingEvent	[NegativePrecedingEvent:9963152] Futile Cycle: ZnT1 mediates the efflux of zinc from the cell
output	[SimpleEntity:29426] Zn2+ [cytosol] [SimpleEntity:111627] HCO3- [cytosol] [SimpleEntity:111627] HCO3- [cytosol]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2009-12-15
reviewed	[InstanceEdit:446289] He, Lei, 2009-11-12 [InstanceEdit:9962967] D'Eustachio, Peter, 2025-08-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104651] R-HSA-442387.3
structureModified	[InstanceEdit:9958441] Stephan, Ralf, 2025-06-20
summation	[Summation:442353] The human gene SLC39A8 encodes the zinc transporter ZIP8 (BI...
(hasEvent)	[Pathway:442380] Zinc influx into cells by the SLC39 gene family [Homo sapiens]
(precedingEvent)	[Reaction:435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages [Homo sapiens] [Reaction:435375] ZnT2 facilitates zinc vesicular sequestration [Homo sapiens] [Reaction:437084] ZnT3 transports zinc into synaptic vesicles [Homo sapiens] [Reaction:437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells [Homo sapiens] [Reaction:437136] SLC30A8 transports Zn2+ from cytosol to secretory granule [Homo sapiens] [Reaction:437139] ZnT8 transports zinc into the Golgi apparatus [Homo sapiens] [Reaction:9820566] ZnT5 transports zinc into the golgi apparatus [Homo sapiens] [NegativePrecedingEvent:9963158] Futile Cycle: ZIP8 mediates zinc influx into cells
(updatedInstance)	[_UpdateTracker:9964706] Update Tracker - [Reaction:442387] ZIP8 mediates zinc influx into cells - v94:[modifyText, removeInput, removeLiteratureReference, removeOutput]
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