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Details on Person SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region

Class:Id	Reaction:442368
_displayName	SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region
_doRelease	TRUE
_timestamp	2025-08-13 17:45:49
authored	[InstanceEdit:442374] Jassal, Bijay, 2009-09-25
catalystActivity	[CatalystActivity:442424] ferrous iron transmembrane transporter activity of SLC40A1:HEPH:6Cu2+ [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:442374] Jassal, Bijay, 2009-09-25
crossReference	[DatabaseIdentifier:9957289] RHEA:28487
edited	[InstanceEdit:433105] Jassal, Bijay, 2009-08-21
input	[SimpleEntity:71067] Fe2+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:442331] In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations [LiteratureReference:904846] Colocalization of ferroportin-1 with hephaestin on the basolateral membrane of human intestinal absorptive cells [LiteratureReference:904844] Decreased hephaestin expression and activity leads to decreased iron efflux from differentiated Caco2 cells
modified	[InstanceEdit:442658] Jassal, Bijay, 2009-09-29 [InstanceEdit:446288] Jassal, Bijay, 2009-11-12 [InstanceEdit:904842] Jassal, Bijay, 2010-07-05 [InstanceEdit:912520] Jassal, Bijay, 2010-07-09 [InstanceEdit:5655819] Jassal, Bijay, 2014-12-09 [InstanceEdit:9025985] D'Eustachio, Peter, 2017-10-16 [InstanceEdit:9028714] Jassal, Bijay, 2017-11-09 [InstanceEdit:9028715] Jassal, Bijay, 2017-11-09 [InstanceEdit:9028716] Jassal, Bijay, 2017-11-09 [InstanceEdit:9028717] Jassal, Bijay, 2017-11-09 [InstanceEdit:9028718] Jassal, Bijay, 2017-11-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9957283] Stephan, Ralf, 2025-06-18 [InstanceEdit:9963151] Stephan, Ralf, 2025-08-13
name	SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region Ferroportin mediates iron influx across the basolateral membrane of enterocytes
negativePrecedingEvent	[NegativePrecedingEvent:9963156] Futile Cycle: SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol
output	[SimpleEntity:435347] Fe2+ [extracellular region]
releaseDate	2009-12-15
reviewed	[InstanceEdit:446289] He, Lei, 2009-11-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105074] R-HSA-442368.4
summation	[Summation:442396] The primary site for absorption of dietary iron is the duode...
(hasEvent)	[Pathway:425410] Metal ion SLC transporters [Homo sapiens] [Pathway:917937] Iron uptake and transport [Homo sapiens]
(normalReaction)	[FailedReaction:5655760] Defective SLC40A1 does not transport Fe3+ from extracellular region to cytosol [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9963149] Futile Cycle: SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region [Reaction:917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780493] Update Tracker - [Reaction:442368] SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region - v63:[add_removeInput, add_removeOutput] [_UpdateTracker:9785094] Update Tracker - [Reaction:442368] SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region - v52:[modifyText] [_UpdateTracker:9790304] Update Tracker - [Reaction:442368] SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region - v34:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
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