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Details on Person VAV2 is a GEF for Rho/Rac family kinases

Class:Id	Reaction:442291
_displayName	VAV2 is a GEF for Rho/Rac family kinases
_doRelease	TRUE
_timestamp	2016-05-23 13:23:52
authored	[InstanceEdit:435013] Akkerman, JW, 2009-09-04
catalystActivity	[CatalystActivity:442283] guanyl-nucleotide exchange factor activity of p-Y172-VAV2 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:442288] Jupe, S, 2009-09-24
edited	[InstanceEdit:435388] Jupe, S, 2009-09-09
input	[Complex:442278] VAV2 Rho/Rac effectors:GDP [cytosol] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
literatureReference	[LiteratureReference:389291] Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product [LiteratureReference:442301] Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1
modified	[InstanceEdit:870420] Jupe, S, 2010-06-08 [InstanceEdit:8874417] Jupe, Steve, 2016-05-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	VAV2 is a GEF for Rho/Rac family kinases
output	[Complex:442290] VAV2 Rho/Rac effectors:GTP [cytosol] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:437936] p-Y348-SYK phosphorylates VAV family [Homo sapiens] [Reaction:437932] p-Y348-SYK binds VAV family [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:870290] Kunapuli, SP, 2010-06-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104878] R-HSA-442291.3
summation	[Summation:442275] Members of the Vav family are guanine nucleotide exchange fa...
(hasEvent)	[Pathway:114604] GPVI-mediated activation cascade [Homo sapiens]
(precedingEvent)	[Reaction:419049] ROCK activation by RHO [Homo sapiens] [BlackBoxEvent:419875] Rac1 stimulation of LIMK1 [Homo sapiens] [Reaction:419906] Activated CDC42 binds to MRCK alpha [Homo sapiens] [Reaction:442555] IRSp53 links Rac to WAVE2 [Homo sapiens] [BlackBoxEvent:442571] Rac1 mediated translocation of cortactin to cell periphery [Homo sapiens] [Reaction:442624] Rac and Cdc42 activate PAK [Homo sapiens]
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No pathways have been reviewed or authored by VAV2 is a GEF for Rho/Rac family kinases (442291)