Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person VAV1 is a GEF for Rho/Rac family GTPases

Class:Id	Reaction:442273
_displayName	VAV1 is a GEF for Rho/Rac family GTPases
_doRelease	TRUE
_timestamp	2019-02-04 18:19:41
authored	[InstanceEdit:435013] Akkerman, JW, 2009-09-04
catalystActivity	[CatalystActivity:442279] guanyl-nucleotide exchange factor activity of p-Y174-VAV1 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:442288] Jupe, S, 2009-09-24
edited	[InstanceEdit:435388] Jupe, S, 2009-09-09
input	[Complex:114543] VAV1 Rho/Rac effectors:GDP [cytosol] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
literatureReference	[LiteratureReference:389291] Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product [LiteratureReference:442301] Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1
modified	[InstanceEdit:870420] Jupe, S, 2010-06-08 [InstanceEdit:8874417] Jupe, Steve, 2016-05-23 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9615273] Orlic-Milacic, Marija, 2018-07-31 [InstanceEdit:9635408] Orlic-Milacic, Marija, 2019-02-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	VAV1 is a GEF for Rho/Rac family GTPases
output	[Complex:114539] VAV1 Rho/Rac effectors:GTP [cytosol] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:437936] p-Y348-SYK phosphorylates VAV family [Homo sapiens] [Reaction:437932] p-Y348-SYK binds VAV family [Homo sapiens] [Reaction:434637] PI(3,4,5)P3 binds VAV1,2,3 [Homo sapiens] [Reaction:437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 [Homo sapiens] [Reaction:437936] p-Y348-SYK phosphorylates VAV family [Homo sapiens] [Reaction:5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
regulatedBy	[NegativeRegulation:8874423] Negative regulation by 'VAV family:PIP2 [plasma membrane]' [PositiveRegulation:8874424] Positive regulation by 'PIP3:VAV1,2,3 [plasma membrane]'
releaseDate	2010-09-21
reviewed	[InstanceEdit:870290] Kunapuli, SP, 2010-06-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105340] R-HSA-442273.6
summation	[Summation:442297] Vav family members are guanine nucleotide exchange factors (...
(hasEvent)	[Pathway:114604] GPVI-mediated activation cascade [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:419875] Rac1 stimulation of LIMK1 [Homo sapiens] [Reaction:419906] Activated CDC42 binds to MRCK alpha [Homo sapiens] [Reaction:442555] IRSp53 links Rac to WAVE2 [Homo sapiens] [BlackBoxEvent:442571] Rac1 mediated translocation of cortactin to cell periphery [Homo sapiens] [Reaction:442624] Rac and Cdc42 activate PAK [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782895] Update Tracker - [Reaction:442273] VAV1 is a GEF for Rho/Rac family GTPases - v58:[addRegulator]
[Change default viewing format]

No pathways have been reviewed or authored by VAV1 is a GEF for Rho/Rac family GTPases (442273)