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Details on Person Binding of VEGFA to VEGFR2 induces receptor dimerization and...
| Class:Id | Summation:4420183 |
|---|---|
| _displayName | Binding of VEGFA to VEGFR2 induces receptor dimerization and... |
| _timestamp | 2014-01-15 10:16:42 |
| created | [InstanceEdit:4420157] Garapati, P V, 2013-08-30 |
| literatureReference | [LiteratureReference:4420165] Biological activity and phosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGF-receptor [LiteratureReference:4420214] Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites [LiteratureReference:4420132] VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis [LiteratureReference:4420136] Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues [LiteratureReference:5218616] Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice [LiteratureReference:5228971] Structure of a VEGF-VEGF receptor complex determined by electron microscopy |
| modified | [InstanceEdit:5218600] Garapati, P V, 2013-12-19 [InstanceEdit:5228340] Jupe, S, 2014-01-10 [InstanceEdit:5228967] Garapati, P V, 2014-01-15 |
| text | Binding of VEGFA to VEGFR2 induces receptor dimerization and autophosphorylation, leading to the recruitment of downstream signalling molecules. Once the two VEGFR2 receptors are cross-linked to each other, via simultaneous interaction with VEGFA dimer, their membrane-proximal Ig-like domain 7s are held in close proximity so that low-affinity homotypic interactions between these domains further stabilise the receptor dimers. This allows for the exact positioning of the intracellular kinase domains resulting in VEGFR2 autophosphorylation (Ruch et al. 2007, Holmes at al. 2007). The major tyrosine residues known to be autophosphorylated are Y801 and Y951 in the kinase-insert domain, Y1054 and Y1059 within the kinase domain, and Y1175 and Y1214 in the C-terminal tail of VEGFR (Dougher-Vermazen et al. 1994, Cunningham et al. 2007, Kendall et al. 1999, Matsumoto et al. 2005). The Y1175 (mice Y1173) is crucial for endothelial and haemopoietic cell development. Mice with muatation Y1173F die between E8.5 and E9.5 from lack of endothelial and haemopoietic development (Sakurai et al. 2005). |
| (summation) | [Reaction:4420117] VEGFR2 autophosphorylates [Homo sapiens] |
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