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Details on Person p-6Y-VEGFR2 binds PLCG1

Class:Id	Reaction:4420153
_displayName	p-6Y-VEGFR2 binds PLCG1
_doRelease	TRUE
_timestamp	2024-03-20 23:21:52
authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
input	[EntityWithAccessionedSequence:202320] PLCG1 [cytosol] [Homo sapiens] [Complex:4420101] VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:4420118] Role of PLCgamma and Ca(2+) in VEGF- and FGF-induced choroidal endothelial cell proliferation [LiteratureReference:195484] A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells
modified	[InstanceEdit:5218856] Garapati, P V, 2013-12-19 [InstanceEdit:5432676] Garapati, P V, 2014-05-12 [InstanceEdit:5490368] Garapati, P V, 2014-05-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9866007] Orlic-Milacic, Marija, 2024-03-20
name	p-6Y-VEGFR2 binds PLCG1
negativePrecedingEvent	[NegativePrecedingEvent:9865998] Futile Cycle: PLCG1 disassociates from VEGFR2 and translocate to PM
output	[Complex:4420203] VEGFA dimer:p-6Y-VEGFR2 dimer:PLCG1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:4420117] VEGFR2 autophosphorylates [Homo sapiens] [Reaction:194310] VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization [Homo sapiens] [Reaction:9691215] VEGFA-165 dimer binds VEGFR2 dimer [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644930] R-HSA-4420153.3
summation	[Summation:4420112] Phospholipase C-gamma 1 (PLCG1) plays a pivotal role in angi...
(hasEvent)	[Pathway:5218921] VEGFR2 mediated cell proliferation [Homo sapiens]
(precedingEvent)	[Reaction:4420121] SFKs phosphorylate PLCG1 [Homo sapiens]
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No pathways have been reviewed or authored by p-6Y-VEGFR2 binds PLCG1 (4420153)