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Details on Person p-6Y-VEGFR2 binds SH2D2A

Class:Id	Reaction:4420143
_displayName	p-6Y-VEGFR2 binds SH2D2A
_doRelease	TRUE
_timestamp	2024-03-20 23:21:56
authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
input	[EntityWithAccessionedSequence:4420125] SH2D2A [cytosol] [Homo sapiens] [Complex:4420101] VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:4420084] VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor [LiteratureReference:4420132] VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis
modified	[InstanceEdit:5218856] Garapati, P V, 2013-12-19 [InstanceEdit:5228340] Jupe, S, 2014-01-10 [InstanceEdit:5228988] Garapati, P V, 2014-01-15 [InstanceEdit:5357631] Garapati, P V, 2014-03-25 [InstanceEdit:5357638] Garapati, P V, 2014-03-25 [InstanceEdit:5432676] Garapati, P V, 2014-05-12 [InstanceEdit:5490368] Garapati, P V, 2014-05-19 [InstanceEdit:9026724] Rothfels, Karen, 2017-10-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9866007] Orlic-Milacic, Marija, 2024-03-20
name	p-6Y-VEGFR2 binds SH2D2A
negativePrecedingEvent	[NegativePrecedingEvent:9865997] Futile Cycle: PLCG1 disassociates from VEGFR2 and translocate to PM
output	[Complex:4420137] VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:4420117] VEGFR2 autophosphorylates [Homo sapiens] [Reaction:194310] VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization [Homo sapiens] [Reaction:9691215] VEGFA-165 dimer binds VEGFR2 dimer [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5645149] R-HSA-4420143.4
summation	[Summation:4420211] Two-hybrid mapping showed that tyrosine 951 (Y951) serves as...
(hasEvent)	[Pathway:4420097] VEGFA-VEGFR2 Pathway [Homo sapiens]
(precedingEvent)	[Reaction:4420140] SRC1-1 binds SH2D2A and is recruited to VEGFR2 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780462] Update Tracker - [Reaction:4420143] p-6Y-VEGFR2 binds SH2D2A - v63:[modifyText]
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No pathways have been reviewed or authored by p-6Y-VEGFR2 binds SH2D2A (4420143)