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Details on Person SFKs phosphorylate PLCG1

Class:Id	Reaction:4420121
_displayName	SFKs phosphorylate PLCG1
_doRelease	TRUE
_timestamp	2014-11-20 02:45:10
authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
catalystActivity	[CatalystActivity:210268] protein tyrosine kinase activity of SRC-1 [cytosol]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:4420203] VEGFA dimer:p-6Y-VEGFR2 dimer:PLCG1 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:4420118] Role of PLCgamma and Ca(2+) in VEGF- and FGF-induced choroidal endothelial cell proliferation [LiteratureReference:4420181] A new tyrosine phosphorylation site in PLC gamma 1: the role of tyrosine 775 in immune receptor signaling [LiteratureReference:3448708] Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes
modified	[InstanceEdit:5218857] Garapati, P V, 2013-12-19 [InstanceEdit:5228988] Garapati, P V, 2014-01-15 [InstanceEdit:5432676] Garapati, P V, 2014-05-12 [InstanceEdit:5490368] Garapati, P V, 2014-05-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SFKs phosphorylate PLCG1
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:4420110] VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:4420153] p-6Y-VEGFR2 binds PLCG1 [Homo sapiens] [Reaction:4420117] VEGFR2 autophosphorylates [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644737] R-HSA-4420121.2
summation	[Summation:4420104] Activation of VEGFR2 has been shown to lead to direct bindin...
(hasEvent)	[Pathway:5218921] VEGFR2 mediated cell proliferation [Homo sapiens]
(precedingEvent)	[Reaction:4420202] PLCG1 disassociates from VEGFR2 and translocate to PM [Homo sapiens]
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No pathways have been reviewed or authored by SFKs phosphorylate PLCG1 (4420121)