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Details on Person VEGFR2 autophosphorylates

Class:Id	Reaction:4420117
_displayName	VEGFR2 autophosphorylates
_doRelease	TRUE
_timestamp	2024-03-20 23:21:38
authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
catalystActivity	[CatalystActivity:4420144] protein tyrosine kinase activity of VEGFA-165 dimer:VEGFR2 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643911] protein tyrosine kinase activity of VEGFA-165 dimer:VEGFR2 dimer [plasma membrane] Biological activity and phosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGF-receptor
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:195402] VEGFA-165 dimer:VEGFR2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:195382] VEGFR2 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:4420214] Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites [LiteratureReference:4420132] VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis [LiteratureReference:4420136] Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues
modified	[InstanceEdit:5218856] Garapati, P V, 2013-12-19 [InstanceEdit:5228340] Jupe, S, 2014-01-10 [InstanceEdit:5359108] Garapati, P V, 2014-04-08 [InstanceEdit:5359109] Garapati, P V, 2014-04-08 [InstanceEdit:5432676] Garapati, P V, 2014-05-12 [InstanceEdit:5490368] Garapati, P V, 2014-05-19 [InstanceEdit:9026720] Rothfels, Karen, 2017-10-23 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9698117] Jassal, Bijay, 2020-08-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9866007] Orlic-Milacic, Marija, 2024-03-20
name	VEGFR2 autophosphorylates
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:4420101] VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:194310] VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization [Homo sapiens] [Reaction:195378] Homodimerization of VEGF proteins [Homo sapiens] [Reaction:9691215] VEGFA-165 dimer binds VEGFR2 dimer [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644315] R-HSA-4420117.6
summation	[Summation:4420183] Binding of VEGFA to VEGFR2 induces receptor dimerization and...
(hasEvent)	[Pathway:4420097] VEGFA-VEGFR2 Pathway [Homo sapiens]
(precedingEvent)	[Reaction:4420099] p-6Y-VEGFR2 binds SHB [Homo sapiens] [Reaction:4420107] p-6Y-VEGFR2 binds SHC-transforming protein 2 [Homo sapiens] [Reaction:4420143] p-6Y-VEGFR2 binds SH2D2A [Homo sapiens] [Reaction:4420153] p-6Y-VEGFR2 binds PLCG1 [Homo sapiens] [Reaction:5218815] p-6Y-VEGFR2 binds NCK [Homo sapiens] [Reaction:5218818] Integrin alphaVbeta3 binds p-6Y-VEGFR2 [Homo sapiens] [Reaction:5218852] p-6Y-VEGFR2 binds PI3K [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776795] Update Tracker - [Reaction:4420117] VEGFR2 autophosphorylates - v74:[addInput]
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No pathways have been reviewed or authored by VEGFR2 autophosphorylates (4420117)