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Details on Person PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2

Class:Id	Reaction:4420083
_displayName	PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2
_doRelease	TRUE
_timestamp	2017-10-23 12:23:38
authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
input	[EntityWithAccessionedSequence:201621] PTK2 [cytosol] [Homo sapiens] [Complex:4420164] VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:4420114] The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration [LiteratureReference:5218500] Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells
modified	[InstanceEdit:5218914] Garapati, P V, 2013-12-20 [InstanceEdit:5228340] Jupe, S, 2014-01-10 [InstanceEdit:5228988] Garapati, P V, 2014-01-15 [InstanceEdit:5357631] Garapati, P V, 2014-03-25 [InstanceEdit:5357638] Garapati, P V, 2014-03-25 [InstanceEdit:5432676] Garapati, P V, 2014-05-12 [InstanceEdit:5490368] Garapati, P V, 2014-05-19 [InstanceEdit:9026706] Rothfels, Karen, 2017-10-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2
output	[Complex:4420141] VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:4420128] SRC-1 phosphorylates SHB [Homo sapiens] [Reaction:4420099] p-6Y-VEGFR2 binds SHB [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644487] R-HSA-4420083.3
summation	[Summation:4420093] SHB binds focal adhesion kinase 1 (FAK1; also known as PTK2)...
(hasEvent)	[Pathway:4420097] VEGFA-VEGFR2 Pathway [Homo sapiens]
(precedingEvent)	[Reaction:5218642] PTK2 autophosphorylates [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780294] Update Tracker - [Reaction:4420083] PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 - v63:[modifyText]
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No pathways have been reviewed or authored by PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (4420083)