Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP

Class:IdReaction:4419978
_displayNameDHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP
_doReleaseTRUE
_timestamp2025-02-26 19:30:51
authored[InstanceEdit:4419985] Jassal, B, 2013-08-29
catalystActivity[CatalystActivity:4419984] transferase activity, transferring alkyl or aryl (other than methyl) groups of DHDDS:NUS1 [endoplasmic reticulum membrane]
compartment[Compartment:12045] endoplasmic reticulum membrane
[Compartment:70101] cytosol
[Compartment:5263266] cytoplasmic side of endoplasmic reticulum membrane
created[InstanceEdit:4419985] Jassal, B, 2013-08-29
crossReference[DatabaseIdentifier:9937283] RHEA:53009
edited[InstanceEdit:4419985] Jassal, B, 2013-08-29
input[SimpleEntity:4419987] E,E-FPP [cytosol]
[SimpleEntity:191362] IPPP [cytosol]
[SimpleEntity:191362] IPPP [cytosol]
[SimpleEntity:191362] IPPP [cytosol]
[SimpleEntity:191362] IPPP [cytosol]
[SimpleEntity:191362] IPPP [cytosol]
[SimpleEntity:191362] IPPP [cytosol]
[SimpleEntity:191362] IPPP [cytosol]
[SimpleEntity:191362] IPPP [cytosol]
[SimpleEntity:191362] IPPP [cytosol]
[SimpleEntity:191362] IPPP [cytosol]
[SimpleEntity:191362] IPPP [cytosol]
[SimpleEntity:191362] IPPP [cytosol]
[SimpleEntity:191362] IPPP [cytosol]
[SimpleEntity:191362] IPPP [cytosol]
[SimpleEntity:191362] IPPP [cytosol]
[SimpleEntity:191362] IPPP [cytosol]
[SimpleEntity:191362] IPPP [cytosol]
[SimpleEntity:191362] IPPP [cytosol]
[SimpleEntity:191362] IPPP [cytosol]
[SimpleEntity:191362] IPPP [cytosol]
internalReviewed[InstanceEdit:9937336] D'Eustachio, Peter, 2025-01-30
isChimericFALSE
literatureReference[LiteratureReference:4419872] Identification and characterization of a cDNA encoding a long-chain cis-isoprenyltranferase involved in dolichyl monophosphate biosynthesis in the ER of brain cells
[LiteratureReference:6806948] Nogo-B receptor is necessary for cellular dolichol biosynthesis and protein N-glycosylation
[LiteratureReference:4419862] Whole-exome sequencing links a variant in DHDDS to retinitis pigmentosa
[LiteratureReference:4420021] Analysis of dolichol in human tissues by high pressure liquid chromatography
modified[InstanceEdit:4420019] Jassal, B, 2013-08-29
[InstanceEdit:4755549] Jassal, B, 2013-10-25
[InstanceEdit:4793944] Jassal, B, 2013-10-29
[InstanceEdit:5099826] Jassal, Bijay, 2013-11-13
[InstanceEdit:6806951] Jassal, Bijay, 2015-10-28
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9910684] D'Eustachio, Peter, 2024-05-16
[InstanceEdit:9937296] D'Eustachio, Peter, 2025-01-30
[InstanceEdit:9939403] D'Eustachio, Peter, 2025-02-26
nameDHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP
n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate => a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate
output[SimpleEntity:4419982] pPPP [cytoplasmic side of endoplasmic reticulum membrane]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2013-12-04
reviewed[InstanceEdit:4793945] D'Eustachio, P, 2013-10-29
[InstanceEdit:9939401] Hill, David P, 2025-02-26
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:6806945] Jassal, Bijay, 2015-10-28
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5644600] R-HSA-4419978.5
structureModified[InstanceEdit:9937296] D'Eustachio, Peter, 2025-01-30
summation[Summation:4419983] The ER membrane-associated enzyme dehydrodolichyl diphosphat...
(hasEvent)[Pathway:446199] Synthesis of dolichyl-phosphate [Homo sapiens]
(normalReaction)[FailedReaction:4755545] Defective DHDDS does not elongate E,E-FPP [Homo sapiens]
(precedingEvent)[Reaction:4419986] Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL [Homo sapiens]
(updatedInstance)[_UpdateTracker:9784020] Update Tracker - [Reaction:4419978] DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP - v55:[addLiteratureReference, modifyText]
[_UpdateTracker:9939619] Update Tracker - [Reaction:4419978] DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP - v92:[removeOutput]
[Change default viewing format]
No pathways have been reviewed or authored by DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (4419978)
Follow Reactome