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Details on Person CTDNEP1:CNEP1R1 dephosphorylates LPIN
Class:Id Reaction:4419948 _displayName CTDNEP1:CNEP1R1 dephosphorylates LPIN _doRelease TRUE _timestamp 2014-11-20 02:50:29 authored [InstanceEdit:5251380] Orlic-Milacic, M, 2014-02-02 catalystActivity [CatalystActivity:4419955] protein serine/threonine phosphatase activity of CTDNEP1:CNEP1R1 [nuclear envelope] compartment [Compartment:13231] nuclear envelope [Compartment:7660] nucleoplasm created [InstanceEdit:4419951] Orlic-Milacic, M, 2013-08-28 edited [InstanceEdit:5251380] Orlic-Milacic, M, 2014-02-02 input [CandidateSet:4419938] p-S106-LPIN [nucleoplasm] [Homo sapiens] [SimpleEntity:113518] H2O [nucleoplasm] isChimeric FALSE literatureReference [LiteratureReference:4419957] Homo sapiens dullard protein phosphatase shows a preference for the insulin-dependent phosphorylation site of lipin1 [LiteratureReference:4419842] Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway [LiteratureReference:4419944] The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth [LiteratureReference:4419961] A conserved phosphatase cascade that regulates nuclear membrane biogenesis [LiteratureReference:549166] Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2 [LiteratureReference:4419942] Phosphorylation of phosphatidate phosphatase regulates its membrane association and physiological functions in Saccharomyces cerevisiae: identification of SER(602), THR(723), AND SER(744) as the sites phosphorylated by CDC28 (CDK1)-encoded cyclin-dependent kinase [LiteratureReference:4419941] A phosphorylation-regulated amphipathic helix controls the membrane translocation and function of the yeast phosphatidate phosphatase [LiteratureReference:4419965] Mitotic lamin disassembly is triggered by lipid-mediated signaling [LiteratureReference:4419967] Lipin is required for efficient breakdown of the nuclear envelope in Caenorhabditis elegans [LiteratureReference:4419964] Inactivation of the C. elegans lipin homolog leads to ER disorganization and to defects in the breakdown and reassembly of the nuclear envelope modified [InstanceEdit:4419975] Orlic-Milacic, M, 2013-08-28 [InstanceEdit:5195404] Orlic-Milacic, M, 2013-12-02 [InstanceEdit:5324615] Orlic-Milacic, M, 2014-02-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name CTDNEP1:CNEP1R1 dephosphorylates LPIN output [CandidateSet:4419925] LPIN [nuclear envelope] [Homo sapiens] [SimpleEntity:113550] Pi [nucleoplasm] precedingEvent
releaseDate 2014-03-12 reviewed [InstanceEdit:5324613] Gorjánácz, Mátyás, 2014-02-10 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:5644933] R-HSA-4419948.2 summation [Summation:4419974] CTDNEP1:CNEP1R1 serine/threonine protein phosphatase complex... (hasEvent) [Pathway:4419969] Depolymerization of the Nuclear Lamina [Homo sapiens] (precedingEvent) [Reaction:5221130] LPIN catalyzes conversion of phosphatidic acid to diacylglycerol [Homo sapiens] [NegativePrecedingEvent:9764057] Futile Cycle: CTDNEP1:CNEP1R1 dephosphorylates LPIN
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