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Details on Person TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene

Class:IdReaction:4411367
_displayNameTCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene
_doReleaseTRUE
_timestamp2017-11-24 19:05:12
authored[InstanceEdit:4415000] Rothfels, K, 2013-08-23
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:4411356] Rothfels, K, 2013-08-23
edited[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
[InstanceEdit:8959863] Orlic-Milacic, Marija, 2017-01-31
input[Complex:4411378] TCF7L1/TCF7L2/LEF1:CTNNB1 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:2127254] MYC gene [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:3322327] Telomerase modulates Wnt signalling by association with target gene chromatin
[LiteratureReference:4411366] Identification of c-MYC as a target of the APC pathway
[LiteratureReference:3322328] The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes
[LiteratureReference:5323447] Myc deletion rescues Apc deficiency in the small intestine
[LiteratureReference:5323448] Myc is required for ?-catenin-mediated mammary stem cell amplification and tumorigenesis
[LiteratureReference:5323413] C-Myc is a critical mediator of the phenotypes of Apc loss in the intestine
[LiteratureReference:5323406] Activation of Wnt and Myc signaling in hepatoblastoma
[LiteratureReference:8951419] RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis
modified[InstanceEdit:4416357] Rothfels, K, 2013-08-25
[InstanceEdit:4518458] Rothfels, K, 2013-09-03
[InstanceEdit:4655167] Rothfels, K, 2013-10-02
[InstanceEdit:5097300] Rothfels, K, 2013-11-11
[InstanceEdit:5146692] Rothfels, K, 2013-11-18
[InstanceEdit:5228746] Rothfels, K, 2014-01-14
[InstanceEdit:5251624] Rothfels, K, 2014-02-04
[InstanceEdit:5323601] Rothfels, K, 2014-02-15
[InstanceEdit:5576931] Rothfels, Karen, 2014-05-27
[InstanceEdit:8951534] Orlic-Milacic, Marija, 2016-12-07
[InstanceEdit:8959882] Orlic-Milacic, Marija, 2017-01-31
[InstanceEdit:8959887] Orlic-Milacic, Marija, 2017-01-31
[InstanceEdit:8959889] Orlic-Milacic, Marija, 2017-01-31
[InstanceEdit:9030002] Orlic-Milacic, Marija, 2017-11-24
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameTCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene
output[Complex:4411387] TCF7L1/TCF7L2/LEF1:CTNNB1:MYC gene [nucleoplasm] [Homo sapiens]
precedingEvent
regulatedBy[NegativeRegulation:8951527] Negative regulation by 'RUNX3:TCF7L2,(LEF1,TCF7L1) [nucleoplasm]'
regulationReference[RegulationReference:9642042] Negative regulation by 'RUNX3:TCF7L2,(LEF1,TCF7L1) [nucleoplasm]' RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis
releaseDate2014-03-12
reviewed[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22
[InstanceEdit:5323527] van Amerongen, R, 2014-02-14
[InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
[InstanceEdit:8959885] Ito, Yoshiaki, 2017-01-31
[InstanceEdit:8959883] Chuang, Linda Shyue Huey, 2017-01-31
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5644558] R-HSA-4411367.6
summation[Summation:4411355] TCF7L1 (also known as TCF3), TCF7L3 (also known as LEF1) and...
(hasEvent)[Pathway:4411364] Binding of TCF/LEF:CTNNB1 to target gene promoters [Homo sapiens]
[Pathway:8951430] RUNX3 regulates WNT signaling [Homo sapiens]
(precedingEvent)[BlackBoxEvent:4411357] TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene [Homo sapiens]
(updatedInstance)[_UpdateTracker:9781599] Update Tracker - [Reaction:4411367] TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene - v60:[addLiteratureReference, addRegulator, modifyText]
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