Query author contributions in Reactome
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Details on Person TCF7L1 (also known as TCF3), TCF7L3 (also known as LEF1) and...
| Class:Id | Summation:4411355 |
|---|---|
| _displayName | TCF7L1 (also known as TCF3), TCF7L3 (also known as LEF1) and... |
| _timestamp | 2017-01-31 15:22:26 |
| created | [InstanceEdit:4411356] Rothfels, K, 2013-08-23 |
| modified | [InstanceEdit:5228735] Rothfels, K, 2014-01-14 [InstanceEdit:5323600] Rothfels, K, 2014-02-15 [InstanceEdit:8951534] Orlic-Milacic, Marija, 2016-12-07 [InstanceEdit:8959869] Orlic-Milacic, Marija, 2017-01-31 |
| text | TCF7L1 (also known as TCF3), TCF7L3 (also known as LEF1) and TCF7L2 (also known as TCF4) have been demonstrated to bind to the MYC gene in vivo and in vitro and to mediate beta-catenin dependent transcription (Park et al, 2009; He et al, 1998; Sierra et al, 2006). Aberrant beta-catenin dependent activation of the MYC gene contributes to oncogenic signaling and cellular proliferation in colorectal and other cancers (see for instance Sansom et al, 2007; Moumen et al, 2013; reviewed in Wilkins and Sansom, 2008; Cairo et al, 2012). Binding of RUNX3 to the CTNNB1:TCF7L2 and possibly to the CTNNB1:LEF1 and TCF7L1 complexes, prevents binding of CTNNB1 complexes to the MYC promoter, thus negatively regulating MYC transcription (Ito et al. 2008). |
| (summation) | [BlackBoxEvent:4411357] TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene [Homo sapiens] [Reaction:4411367] TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene [Homo sapiens] |
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No pathways have been reviewed or authored by TCF7L1 (also known as TCF3), TCF7L3 (also known as LEF1) and... (4411355)
