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Details on Person Activated NLK phosphorylates TCF7L2 and LEF1 at serine and t...
| Class:Id | Summation:4411354 |
|---|---|
| _displayName | Activated NLK phosphorylates TCF7L2 and LEF1 at serine and t... |
| _timestamp | 2013-10-07 19:43:26 |
| created | [InstanceEdit:4411356] Rothfels, K, 2013-08-23 |
| modified | [InstanceEdit:4518427] Rothfels, K, 2013-09-03 [InstanceEdit:4663863] Rothfels, K, 2013-10-07 |
| text | Activated NLK phosphorylates TCF7L2 and LEF1 at serine and threonine residues that lie in the central region between the DNA-binding and beta-catenin interaction domains. Phosphorylation does not affect the ability of TCF/LEF to bind to beta-catenin, but the phosphorylated complex is not able to bind to target DNA or activate transcription as assessed by EMSA and reporter gene assays (Ishitani et al, 2003b). |
| (summation) | [Reaction:4411383] NLK phosphorylates TCF/LEF [Homo sapiens] |
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No pathways have been reviewed or authored by Activated NLK phosphorylates TCF7L2 and LEF1 at serine and t... (4411354)
