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Details on Person NOTCH1 PEST domain mutants bind HES5 promoter

Class:Id	Reaction:4396401
_displayName	NOTCH1 PEST domain mutants bind HES5 promoter
_doRelease	TRUE
_timestamp	2015-08-05 19:35:57
authored	[InstanceEdit:2958607] Orlic-Milacic, M, 2013-01-04
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4396405] Orlic-Milacic, M, 2013-08-23
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
edited	[InstanceEdit:2980626] Jassal, B, 2013-01-09
entityFunctionalStatus	[EntityFunctionalStatus:2775823] gain_of_function of NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm]
input	[EntityWithAccessionedSequence:2197557] HES5 gene [nucleoplasm] [Homo sapiens] [Complex:2220989] NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1911382] Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes
modified	[InstanceEdit:6789899] Orlic-Milacic, Marija, 2015-08-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOTCH1 PEST domain mutants bind HES5 promoter
normalReaction	[Reaction:4396379] NOTCH1 Coactivator Complex binds HES5 promoter [Homo sapiens]
output	[Complex:4396397] NOTCH1 PEST Domain Mutants Coactivator Complex:HES5 Gene [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:2220964] NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML [Homo sapiens] [Reaction:2220982] NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) [Homo sapiens]
releaseDate	2012-03-12
reviewed	[InstanceEdit:3110296] Haw, R, 2013-02-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:4545054] R-HSA-4396401.3
summation	[Summation:4396390] NICD1 PEST domain mutants coactivator complexes are expected...
(hasEvent)	[Pathway:2644606] Constitutive Signaling by NOTCH1 PEST Domain Mutants [Homo sapiens] [Pathway:2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784161] Update Tracker - [Reaction:4396401] NOTCH1 PEST domain mutants bind HES5 promoter - v54:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by NOTCH1 PEST domain mutants bind HES5 promoter (4396401)