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Details on Person Promoters of Hey1, Hey and Heyl genes contain conserved RBPJ...
| Class:Id | Summation:4396381 |
|---|---|
| _displayName | Promoters of Hey1, Hey and Heyl genes contain conserved RBPJ... |
| _timestamp | 2026-03-17 14:11:04 |
| created | [InstanceEdit:4396385] Orlic-Milacic, M, 2013-08-22 |
| modified | [InstanceEdit:9982319] May, Bruce, 2026-02-16 [InstanceEdit:9985246] May, Bruce, 2026-03-17 |
| text | Promoters of Hey1, Hey and Heyl genes contain conserved RBPJ (CSL) binding sites (Maier and Gessler 2000). Cotransfection experiments in mouse fibroblast cell line NIH3T3, human embryonic kidney cell line HEK293 and African green monkey kidney cell line COS-7 showed that a recombinant mouse NICD1 activates transcription of a reporter luciferase gene fused to promoters of either mouse Hey1, Hey2 or Heyl. NICD1-mediated transcriptional activation is lost when RBPJ sites in Hey1 promoter are deleted by PCR-directed mutagenesis (Maier and Gessler 2000). Chromatin immunoprecipitation indicates that Rbpj does not bind the Hey1 or HeyL genes constitutively, but binds only after forming a coactivator complex with Nicd1 (Castel et al. 2013). |
| (summation) | [Reaction:4396387] mNOTCH1 coactivator complex bind promoters of Hey genes [Mus musculus] |
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No pathways have been reviewed or authored by Promoters of Hey1, Hey and Heyl genes contain conserved RBPJ... (4396381)
