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Details on Person Membrane depolarization upon activation of Ca impermeable AMPA receptors

Class:Id	Reaction:438037
_displayName	Membrane depolarization upon activation of Ca impermeable AMPA receptors
_doRelease	TRUE
_timestamp	2018-11-08 16:59:27
authored	[InstanceEdit:442774] Mahajan, SS, 2009-09-29
catalystActivity	[CatalystActivity:399708] excitatory extracellular ligand-gated monoatomic ion channel activity of Ca impermeable AMPA receptor ligand complex [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:438042] Mahajan, SS, 2009-09-23
edited	[InstanceEdit:422554] Gillespie, ME, 2009-06-02 00:56:21 [InstanceEdit:9628239] Orlic-Milacic, Marija, 2018-11-07
input	[SimpleEntity:74113] Na+ [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:438035] AMPA receptor-mediated excitotoxicity in human NT2-N neurons results from loss of intracellular Ca2+ homeostasis following marked elevation of intracellular Na+
modified	[InstanceEdit:438061] Mahajan, SS, 2009-09-23 [InstanceEdit:444284] Mahajan, SS, 2009-10-23 [InstanceEdit:444801] Mahajan, SS, 2009-10-26 [InstanceEdit:445391] Mahajan, SS, 2009-10-30 [InstanceEdit:446748] Mahajan, SS, 2009-11-17 [InstanceEdit:446817] Mahajan, SS, 2009-11-17 [InstanceEdit:447282] Mahajan, SS, 2009-11-21 [InstanceEdit:9609394] Orlic-Milacic, Marija, 2018-05-23 [InstanceEdit:9615245] Orlic-Milacic, Marija, 2018-07-31 [InstanceEdit:9620498] Orlic-Milacic, Marija, 2018-09-24 [InstanceEdit:9628237] Orlic-Milacic, Marija, 2018-11-07 [InstanceEdit:9628240] Orlic-Milacic, Marija, 2018-11-07 [InstanceEdit:9628439] Orlic-Milacic, Marija, 2018-11-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Membrane depolarization upon activation of Ca impermeable AMPA receptors
output	[SimpleEntity:83910] Na+ [cytosol]
regulatedBy	[PositiveRegulation:9620496] Positive regulation by 'Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane]'
releaseDate	2009-12-15
reviewed	[InstanceEdit:446792] Tukey, D, 2009-11-17 [InstanceEdit:9627687] Yi, Feng, 2018-11-02 [InstanceEdit:9628437] Hansen, Kasper B, 2018-11-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104985] R-HSA-438037.4
summation	[Summation:444285] Membrane depolarization occurs due to glutamate dependent ac...
(hasEvent)	[Pathway:438066] Unblocking of NMDA receptors, glutamate binding and activation [Homo sapiens]
(precedingEvent)	[Reaction:432162] Unblocking of GRIN1:GRIN2 NMDA receptors [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778738] Update Tracker - [Reaction:438037] Membrane depolarization upon activation of Ca impermeable AMPA receptors - v67:[addRegulator, modifyText] [_UpdateTracker:9779184] Update Tracker - [Reaction:438037] Membrane depolarization upon activation of Ca impermeable AMPA receptors - v66:[modifyText, removeInput, removeOutput]
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