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Details on Person activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3

Class:Id	Reaction:438019
_displayName	activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
_doRelease	TRUE
_timestamp	2010-12-02 14:34:46
authored	[InstanceEdit:438031] Shamovsky, V, 2009-09-22
catalystActivity	[CatalystActivity:437955] protein serine/threonine/tyrosine kinase activity of phospho MKK3/ phospho MKK6 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:438021] Shamovsky, V, 2009-09-22
edited	[InstanceEdit:668815] Shamovsky, V, 2010-05-04
inferredFrom	[Reaction:450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 [Homo sapiens]
input	[SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [Complex:442951] p38 MAPK : MAPKAPK 2 or MAPKAPK3 [nucleoplasm] [Gallus gallus]
literatureReference	[LiteratureReference:442901] Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine [LiteratureReference:442893] MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
modified	[InstanceEdit:442970] Shamovsky, V, 2009-09-29 [InstanceEdit:446262] Shamovsky, V, 2009-11-11 [InstanceEdit:571397] Shamovsky, V, 2010-04-09 [InstanceEdit:674750] Shamovsky, V, 2010-05-05 [InstanceEdit:680258] Shamovsky, V, 2010-05-05 [InstanceEdit:796988] Shamovsky, V, 2010-05-24 [InstanceEdit:844697] Shamovsky, V, 2010-05-28 [InstanceEdit:1004540] D'Eustachio, P, 2010-11-09 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
output	[SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [Complex:442905] phospho -p38 MAPK : MAPKAPK 2 or MAPKAPK3 [nucleoplasm] [Gallus gallus]
precedingEvent	[Reaction:442938] activated MAPK3/MAPK6 migrates to nucleus [Gallus gallus] [Reaction:437984] Phosphorylation of MKK3/MKK6 by activated TAK1 [Gallus gallus]
releaseDate	2010-12-14
reviewed	[InstanceEdit:789693] D'Eustachio, P, 2010-05-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1104582] R-GGA-438019.2
summation	[Summation:444066] The MAPK level components of this cascade are p38MAPK-alpha,...
(hasEvent)	[Pathway:437980] Activated TAK1 mediates p38 MAP kinase phosphorylation [Gallus gallus]
(precedingEvent)	[Reaction:442913] Active p38 MAPK phosphorylates MAPKAPK2 or 3 [Gallus gallus] [Reaction:446241] Downregulation of MAP kinases by MAPK phosphatases [Gallus gallus]
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No pathways have been reviewed or authored by activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (438019)