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Details on Person Activated JNK migrates to the nucleoplasm

Class:Id	Reaction:437995
_displayName	Activated JNK migrates to the nucleoplasm
_doRelease	TRUE
_timestamp	2010-12-02 14:40:01
authored	[InstanceEdit:438031] Shamovsky, V, 2009-09-22
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm [Compartment:13231] nuclear envelope
created	[InstanceEdit:438021] Shamovsky, V, 2009-09-22
edited	[InstanceEdit:668815] Shamovsky, V, 2010-05-04
inferredFrom	[Reaction:450348] Activated human JNKs migrate to nucleoplasm [Homo sapiens]
input	[CandidateSet:437957] phosphorylated JNK homologs [cytosol] [Gallus gallus]
literatureReference	[LiteratureReference:208214] A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion. [LiteratureReference:500491] Evidence of functional modulation of the MEKK/JNK/cJun signaling cascade by the low density lipoprotein receptor-related protein (LRP) [LiteratureReference:500486] Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK
modified	[InstanceEdit:446231] Shamovsky, V, 2009-11-11 [InstanceEdit:451332] Shamovsky, V, 2010-01-05 [InstanceEdit:571293] Shamovsky, V, 2010-04-09 [InstanceEdit:674706] Shamovsky, V, 2010-05-05 [InstanceEdit:680254] Shamovsky, V, 2010-05-05 [InstanceEdit:749435] Shamovsky, V, 2010-05-18 [InstanceEdit:796980] Shamovsky, V, 2010-05-24 [InstanceEdit:844693] Shamovsky, V, 2010-05-28 [InstanceEdit:1004540] D'Eustachio, P, 2010-11-09 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated JNK migrates to the nucleoplasm
output	[CandidateSet:438012] phosphorylated JNK homologs [nucleoplasm] [Gallus gallus]
precedingEvent	[Reaction:438005] MKK4 phosphorylates JNK [Gallus gallus] [Reaction:437999] Phosphorylation of MKK4 by activated TAK1 [Gallus gallus]
releaseDate	2010-12-14
reviewed	[InstanceEdit:789693] D'Eustachio, P, 2010-05-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1105584] R-GGA-437995.2
summation	[Summation:446230] Shortly after phosphorylation JNKs are translocated to nucl...
(hasEvent)	[Pathway:437986] Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation [Gallus gallus]
(precedingEvent)	[Reaction:438026] Activation and dimerization of c-JUN in the nucleus [Gallus gallus] [Reaction:446241] Downregulation of MAP kinases by MAPK phosphatases [Gallus gallus]
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No pathways have been reviewed or authored by Activated JNK migrates to the nucleoplasm (437995)