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Details on Person Phosphorylation of MKK3/MKK6 by activated TAK1

Class:Id	Reaction:437984
_displayName	Phosphorylation of MKK3/MKK6 by activated TAK1
_doRelease	TRUE
_timestamp	2010-12-02 14:41:43
authored	[InstanceEdit:438031] Shamovsky, V, 2009-09-22
catalystActivity	[CatalystActivity:434076] protein serine/threonine kinase activity of Activated chicken TAK1 complexes [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:438021] Shamovsky, V, 2009-09-22
edited	[InstanceEdit:668815] Shamovsky, V, 2010-05-04
inferredFrom	[Reaction:450346] activated human TAK1 phosphorylates MKK3/MKK6 [Homo sapiens]
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [CandidateSet:437632] MKK3/MKK6 [cytosol] [Gallus gallus]
literatureReference	[LiteratureReference:438028] Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction [LiteratureReference:437996] Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes [LiteratureReference:438014] Essential function for the kinase TAK1 in innate and adaptive immune responses
modified	[InstanceEdit:442968] Shamovsky, V, 2009-09-29 [InstanceEdit:446255] Shamovsky, V, 2009-11-11 [InstanceEdit:451551] Shamovsky, V, 2010-01-05 [InstanceEdit:571367] Shamovsky, V, 2010-04-09 [InstanceEdit:674735] Shamovsky, V, 2010-05-05 [InstanceEdit:680256] Shamovsky, V, 2010-05-05 [InstanceEdit:796984] Shamovsky, V, 2010-05-24 [InstanceEdit:844696] Shamovsky, V, 2010-05-28 [InstanceEdit:975721] Shamovsky, V, 2010-10-02 [InstanceEdit:977264] D'Eustachio, P, 2010-10-15 [InstanceEdit:977267] D'Eustachio, P, 2010-10-15 [InstanceEdit:1004540] D'Eustachio, P, 2010-11-09 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:1063710] Shamovsky, V, 2010-11-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of MKK3/MKK6 by activated TAK1
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [CandidateSet:437977] phospho MKK3/ phospho MKK6 [cytosol] [Gallus gallus]
precedingEvent	[Reaction:433957] Activation of recruited TAK1 [Gallus gallus] [Reaction:433950] TRAF6 recruits TAK1 kinase complex [Gallus gallus] [Reaction:451447] Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 [Gallus gallus] [Reaction:451463] pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex [Gallus gallus]
releaseDate	2010-12-14
reviewed	[InstanceEdit:789693] D'Eustachio, P, 2010-05-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1105880] R-GGA-437984.2
summation	[Summation:444068] MKK3 and MKK6 are two closely related dual-specificity prote...
(hasEvent)	[Pathway:437980] Activated TAK1 mediates p38 MAP kinase phosphorylation [Gallus gallus]
(precedingEvent)	[Reaction:442938] activated MAPK3/MAPK6 migrates to nucleus [Gallus gallus]
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